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TranscriptomicsSYCP2 recruits HORMAD2 for chromosome-axis-associated ATR signaling, unsynapsed chromatin silencing, and synapsis surveillance in meiosis
Meiotic progression in mammals is governed by tightly coordinated transcriptional programs and surveillance mechanisms that ensure the successful pairing, synapsis, and segregation of homologous chromosomes. In spermatocytes, homolog pairing is safeguarded by the pachytene checkpoint, whose mechanis...
ORGANISM(S): Mus musculus 
2026-06-18 | E-MTAB-16317 | biostudies-arrayexpress
GenomicsSRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice [RNA-seq]
SRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice [RNA-seq]
PRJNA944983 | ENA
UnknownDNA double-strand break end synapsis by DNA loop extrusion.
Not available
S-EPMC10079674 | biostudies-literature
TranscriptomicsSRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice [RNA-seq]
Homologous pairing and synapsis are essential in meiotic prophase I during spermatogenesis. However, the underlying mechanisms of how alternative splicing (AS) functions in homologous pairing and synapsis remain largely unclear. We reveal that SRSF1 is essential for gene expression and AS in homolog...
ORGANISM(S): Mus musculus 
2024-01-09 | GSE227403 | GEO
OtherSRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice [CLIP-seq]
Homologous pairing and synapsis are essential in meiotic prophase I during spermatogenesis. However, the underlying mechanisms of how alternative splicing (AS) functions in homologous pairing and synapsis remain largely unclear. We reveal that SRSF1 is essential for gene expression and AS in homolog...
ORGANISM(S): Mus musculus 
2024-01-08 | GSE227303 | GEO
UnknownA pathway for synapsis initiation during zygotene in Drosophila oocytes.
Not available
S-EPMC12823172 | biostudies-literature
UnknownSpindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans.
Not available
S-EPMC4621841 | biostudies-literature
ProteomicsIntegrative Structural Model of DNA-PK Synapsis
In non-homologous end joining repair of DNA double strand breaks, DNA dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/80 binds the free DNA ends forming the holoenzyme DNA-PK. DNA-PK synapses across the break to tether the broken ends in the initial long range synaptic complex. We gen...
ORGANISM(S): Homo sapiens (Human) 
2021-01-20 | PXD017931 | Pride
Dna-pk Hydrogen deuterium exchange Crosslinking 
UnknownDirect Visualization Reveals Kinetics of Meiotic Chromosome Synapsis.
Not available
S-EPMC4565782 | biostudies-literature
TranscriptomicsScreening of genes involved in chromosome segregation in meiosis I
Prophase I of meiosis involves dynamic chromosome segregation processes including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility or recur...
ORGANISM(S): Mus musculus 
2012-06-03 | E-GEOD-35734 | biostudies-arrayexpress
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