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MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
TranscriptomicsTranscription profiling of mouse skeletal muscle to detect genes that regulate motor axon growth and differentiation
These experiments are designed to discover genes that are expressed selectively by synaptic nuclei in skeletal muscle with the particular goal of identifying genes that regulate motor axon growth and differentiation. We plan to isolate RNA from the dissected synaptic region of skeletal muscle and fr...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2873 | biostudies-arrayexpress
ProteomicsAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neuro-transmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the en...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-17 | PXD006413 | Pride
Excitatory synaptic transmission Proteomic analysis Intellectual disability Ampa-receptor biogenesis complexes 
TranscriptomicsHaploinsufficiency in bromodomain containing 2 (Brd2) gene remodels synaptic transmission in male mouse striatum
Our previous work confirmed that Brd2+/- mouse presents the sex specific characteristics of juvenile myoclonic epilepsy, a subsyndrome of idiopathic generalized epilepsy. Here, we investigated the role of Brd2 gene in modulating the genomic fabrics responsible for the glutamatergic, GABAergic, dopam...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-72562 | biostudies-arrayexpress
TranscriptomicsRemodeling of synaptic transmission genomic fabrics in the hypothalamic arcuate nucleus of a rat female model of infantile spasms
We profiled the whole transcriptomes of female rat hypothalamic arcuate nuclei to determine the remodeling of the genomic fabrics responsible for the glutamatergic, GABAergic, dopaminergic, cholinergic and serotonergic transmission in epilepsy and recovery following different treatments. The rats we...
ORGANISM(S): Rattus norvegicus 
2016-07-20 | E-GEOD-84585 | biostudies-arrayexpress
TranscriptomicsHaploinsufficiency in bromodomain containing 2 (Brd2) gene remodels synaptic transmission in female mouse striatum in a sex-specific manner
Our previous work showed that Brd2+/- mouse models the sex specific characteristics of juvenile myoclonic epilepsy, a subsyndrome of idiopathic generalized epilepsy. Here, we investigated a role of Brd2 gene in modulating the genomic fabrics responsible for the glutamatergic, GABAergic, dopaminergic...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-72563 | biostudies-arrayexpress
TranscriptomicsExpression profiles of globular bushy cells (GBCs) during maturation
Calyx of Held giant presynaptic terminals in the medial nucleus of the trapezoid body of the auditory brainstem form axosomatic synapses that have advanced to one of the best-studied synaptic system of the mammalian brain. As the auditory system matures and adjusts to high fidelity synaptic transmis...
ORGANISM(S): Rattus norvegicus 
2014-06-24 | E-GEOD-49599 | biostudies-arrayexpress
GenomicsNeuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
PRJNA543517 | ENA
TranscriptomicsComparative transcriptome analysis of APPs?-DM and APLP2-KO brains
Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and of its proteolytic fragments are still poorly understood. The secreted APPs? ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The ?-secretase g...
ORGANISM(S): Mus musculus 
2011-05-10 | E-GEOD-27888 | biostudies-arrayexpress
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