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Bone morphogenetic protein (BMP) signaling is known to support differentiation of human embryonic stem cells (hESCs) into mesoderm and extraembryonic lineages, whereas other signaling pathways can largely influence this lineage specification. Here, we set out to reinvestigate the influence of ACTIVI...
ORGANISM(S): Homo sapiens 
TFEB, a bHLH-leucine zipper transcription factor belonging to the MiT/TFE family, globally modulates cell metabolism by regulating autophagy and lysosomal functions. Remarkably, loss of TFEB in mice causes embryonic lethality due to severe defects in placentation associated with aberrant vasculariza...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052342 | Pride
MSX2 safeguards syncytiotrophoblast fate of human TSCs
In most mammalian species, a critical step of placental development is the fusion of trophoblast cell into a multinucleated syncytiotrophoblast layer, which separates the fetal and maternal blood circulations. Advancement in understanding this process came from the identification of two pairs of env...
ORGANISM(S): Mus musculus 
TFEB controls syncytiotrophoblast formation and estrogen production in placenta
TFEB controls syncytiotrophoblast formation and estrogen production in placenta [ChIP-Seq]
Mitochondrial-Targeted Antioxidant Attenuates Preeclampsia-Like Phenotypes Induced by Syncytiotrophoblast-Specific Gαq Signaling
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