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MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
UnknownAntimicrobial Synergy Testing: Comparing the Tobramycin and Ceftazidime Gradient Diffusion Methodology Used in Assessing Synergy in Cystic Fibrosis-Derived Multidrug-Resistant Pseudomonas aeruginosa.
Not available
S-EPMC8388873 | biostudies-literature
UnknownAntistaphylococcal activity of DX-619 alone and in combination with vancomycin, teicoplanin, and linezolid assessed by time-kill synergy testing.
Not available
S-EPMC1855475 | biostudies-literature
UnknownPrevalent Synergy and Antagonism Among Antibiotics and Biocides in Pseudomonas aeruginosa.
Not available
S-EPMC7889964 | biostudies-literature
TranscriptomicsMevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition
Bone sarcomas are rare and aggressive pediatric cancers with limited progress in targeted therapy development, partly due to the poor physiological relevance of conventional two-dimensional (2D) culture systems used for preclinical testing. To address this gap, we developed a standardized three-dime...
ORGANISM(S): Homo sapiens 
2026-05-21 | GSE332586 | GEO
GenomicsMevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition
Mevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition
PRJNA1468652 | ENA
UnknownIn vitro evaluation of tigecycline synergy testing with nine antimicrobial agents against Enterobacter cloacae clinical strains.
Not available
S-EPMC11527652 | biostudies-literature
UnknownSystematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems.
Not available
S-EPMC3811454 | biostudies-literature
UnknownPancreatic Cancer Organoids in the Field of Precision Medicine: A Review of Literature and Experience on Drug Sensitivity Testing with Multiple Readouts and Synergy Scoring.
Not available
S-EPMC8833348 | biostudies-literature
UnknownFast detection of synergy and antagonism in antifungal combinations used against Candida albicans clinical isolates.
Not available
S-EPMC12528425 | biostudies-literature
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