We discovered SYNJ2BP is an OMM-localized RNA binding protein. We identified the potential mRNA clients of SYNJ2BP by RIP-seq and validated by CLIP-qPCR.
Mitochondrial quality control failure is frequently observed in neurodegenerative diseases. The detection of damaged mitochondria by stabilization of PTEN-induced kinase 1 (PINK1) requires transport of Pink1 mRNA by tethering it to the mitochondrial surface. Here, we report that inhibition of AMPK b...
