Analysis of patient-specific nucleotide variants is a cornerstone of personalised medicine. Although only 2% of the genomic sequence is protein-coding, mutations occurring in these regions have the potential to influence protein structure and may have severe impact on disease aetiology. Of special i...
The most commonly used genome annotation processes are to a great extent based on computational methods. However, those can only predict genes that have been described earlier or that have sequence signatures indicative of a gene function. We reported a synonymous proteogenomic approach for experime...
Synthetic genome recoding offers a powerful approach to imparting new capabilities to organisms. While monumental achievements have been made in prokaryotes, genome-wide synonymous codon compression in eukaryotes remains challenging due to limited understanding of "design rules" and the physiologica...
