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MetabolomicsMetabolic Profiling of Synovial Fluid in Human Temporomandibular Joint Osteoarthritis

INTRODUCTION: Temporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA. The present study aime...

2025-05-27 | MTBLS9665 | MetaboLights
MetabolomicsMetabolic Profiling of Synovial Fluid in Human Temporomandibular Joint Osteoarthritis

INTRODUCTION: Temporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA. The present study aime...

2025-05-27 | MTBLS9662 | MetaboLights
MetabolomicsSynovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies
Osteoarthritis (OA), osteochondrosis (OC), and synovial sepsis in horses cause loss of function and pain. Reliable biomarkers are required to achieve accurate and rapid diagnosis, with synovial fluid (SF) holding a unique source of biochemical information. Nuclear magnetic resonance (NMR) spectrosco...
2018-07-20 | MTBLS543 | MetaboLights
MetabolomicsMetabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging

BACKGROUND: Palmar osteochondral disease (POD) is a common cause of lameness in competition horses. Magnetic resonance imaging (MRI) is the most sensitive diagnostic modality currently available, however it may not be financially or logistically practical for routine screening o...

2021-11-12 | MTBLS1435 | MetaboLights
MetabolomicsNon-targeted metabolomics analysis of synovial fluid from TMD patients
This study performed non-targeted metabolomics detection on 62 human joint cavity lavage fluid samples using UHPLC-QE-MS. Metabolites were extracted with methanol:acetonitrile (1:1), separated on a Waters ACQUITY UPLC BEH Amide column, and detected by Orbitrap Exploris 120 mass spectrometer in both ...
2026-09-23 | MTBLS14238 | MetaboLights
Metabolomics1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their underlying etiologies are markedly different. We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF). SF was a...
2018-10-11 | MTBLS564 | MetaboLights
Metabolomics1H-NMR-Based Analysis for Exploring Knee Synovial Fluid Metabolite Changes after Local Cryotherapy in Knee Arthritis Patients
Rehabilitation using cryotherapy has widely been used in inflammatory diseases to relieve pain and decrease the disease activity. The aim of this study was to explore the metabolite changes in inflammatory knee-joint synovial fluids following local cryotherapy treatment (ice or cold CO2). We used pr...
2020-11-10 | MTBLS1894 | MetaboLights
TranscriptomicsRNA-seq of synovial biopsies from rheumatoid arthritis patients
Synovial biopsies from rheumatoid arthritis patients were obtained and profiled using RNA-seq. Patients were stratified according to the number of swollen joints they had (SJC, swollen joint count) and divided in three groups for the differential expression analysis: None (SJC = 0), Low (1<= SJC <= ...
ORGANISM(S): Homo sapiens 
2021-04-26 | E-MTAB-6684 | biostudies-arrayexpress
MetabolomicsDetermining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament disease

OBJECTIVES: This study used hydrogen nuclear magnetic resonance spectroscopy (1H NMR) for the first-time to examine differences in the metabolomic profile of stifle joint synovial fluid from dogs with cranial cruciate ligament rupture with and without meniscal injuries, in order ...

2025-08-14 | MTBLS6050 | MetaboLights
TranscriptomicsSingle cell RNA-sequencing of the human synovium in inflammatory arthritis
The study presents: - an optimized synovium dissociation protocol for single cell RNA-sequencing studies of the human synovium. The protocol enables the isolation of high yield of viable synovial cells from prospectively collected fresh synovial biopsies from patients with inflammatory arthritis wi...
ORGANISM(S): Homo sapiens 
2024-04-21 | E-MTAB-11791 | biostudies-arrayexpress
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