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MetabolomicsSynthetic Microbial Communities Improve Wheat Stem Base Rot and Promote Wheat Growth by Regulating Rhizosphere Microbial Communities

Background

Wheat crown rot (WCR) caused by Fusarium spp. lacks durable, sustainable control. Engineering the rhizosphere with defined synthetic microbial communities (SynComs) offers a route to combined disease suppression and growth promotion. We aimed to build a cross-kingdom SynCom and e...

2025-09-06 | MTBLS12945 | MetaboLights
MetabolomicsNarrow-spectrum resource-utilizing bacteria drive the stability of synthetic communities through enhancing metabolic interactions
The importance of synthetic microbial communities in agriculture is increasingly being recognized, but methods for constructing targeted synthetic communities using existing microbial resources remain limited. In this study, six plant beneficial bacterial strains with distinct capacities for utilizi...
2025-07-11 | MTBLS12572 | MetaboLights
MetabolomicsA synthetic community system for probing microbial interactions driven by exometabolites
Despite that most microorganisms live as part of community, we have modest knowledge about the interactions among microbial community members in nature, and the implications of those interactions for emergent community properties or ecosystem-relevant functions. To facilitate advances in understandi...
2017-10-26 | MTBLS525 | MetaboLights
MetabolomicsWild soybean rhizosphere microbiomes buffer continuous cropping obstacles in cultivated soybean via functional cross-kingdom synthetic communities

A cross-kingdom synthetic community (SSC) derived from wild soybean rhizosphere soil was constructed and inoculated onto cultivated soybeans suffering from continuous cropping obstacles. Root exudates from cultivated soybeans were collected before and after inoculation with the SSC via a hydropon...

2026-03-14 | MTBLS13803 | MetaboLights
MetabolomicsSilent guardians: Potentiators enhance synthetic microbiomes to combat co-contamination

Environmental co-contamination presents significant challenges. To tackle these, while microbial consortia offer advantages over single-strain approaches, such as functional redundancy and synergistic degradation, rationally designing effective synthetic microbiomes specifically for complex ...

2025-11-20 | MTBLS12809 | MetaboLights
MetabolomicsCross-kingdom synthetic microbiota suppresses wheat Fusarium crown rot by remodeling the rhizosphere microbiome and metabolome

Wheat is a major staple crop grown across the globe. Fusarium crown rot (FCR) of wheat, caused by Fusarium pseudograminearum, is a destructive soil-borne disease that lacks effective sustainable control measures. Here, we assembled a cross-kingdom synthetic microbial community (SMC) comprising Tr...

2025-09-06 | MTBLS12946 | MetaboLights
MetabolomicsMetabolic network construction reveals probiotic-specific colonization resistance in a synthetic small intestinal community

The gut microbiota is essential to host health. Probiotics can be used as a microbiota targeted therapy to improve host health. However, probiotic molecular mechanisms of action and probiotics targeting the small intestinal microbiota are often not elucidated. In this study, we construct a three ...

2024-09-26 | MTBLS7370 | MetaboLights
MetabolomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Multi-omics analyses are increasingly employed in microbiome studies to obtain a holistic view of molecular changes occurring within microbial communities exposed to different conditions. However, it is not always clear to what extent each omics data type contributes to our understanding of the comm...
2022-12-08 | MTBLS3129 | MetaboLights
ProteomicsAnaerobic synthetic microbial communities
Anaerobic microbial communities play a critical role in biogeochemical cycles through complex networks of interactions that influence community structure, stability, and functionality. This study investigates the metabolic interactions within synthetic communities composed of a cellulolytic bacteriu...
ORGANISM(S): Methanothrix soehngenii GP6 Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) Methanospirillum hungatei JF-1 Desulfovibrio vulgaris str. Hildenborough 
2025-09-22 | PXD056517 | Pride
Sulfate-reducing bacteria Cellulose degrader Methanogen 
TranscriptomicsTemporal RNASeq of C. difficile cultured within synthetic multispecies biofilm relative to C. difficile monoculture biofilms.
This experiment was performed largely to capture the dynamic transcriptional changes occurring in C. difficile when cultured within a 9 species synthetic gut communal consortium over a 48 h time series when cultured as a biofilm in vitro.
ORGANISM(S): Clostridioides difficile 
2026-09-23 | E-MTAB-15646 | biostudies-arrayexpress
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