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TranscriptomicsTranscription profiling by array of human circulating endothelial cells before and after Iloprost infusion in patients with progressive Systemic sclerosis.
Gene expression profiling in circulating endothelial cells before and after Iloprost infusion in patients with progressive Systemic sclerosis.
ORGANISM(S): Homo sapiens 
2010-06-28 | E-MEXP-2769 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human microvascular endothelial cells in systemic sclerosis
Patients with the diffuse avascular form of Systemic Sclerosis (SSc) and healthy controls (N) were used as sources of microvascular endothelial cells (MVEC). MVEC were obtained from biopsies of involved skin of the hands in 6 SSc patients and from 6 healthy patients undergoing surgery for traumatic ...
ORGANISM(S): Homo sapiens 
2005-08-30 | E-MEXP-417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma vs biopsies from normal individiduals
We used DNA microarrays to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma and compared those to the patterns of gene expression seen in biopsies from normal, unaffected individuals.
ORGANISM(S): Homo sapiens 
2013-01-30 | E-MEXP-32 | biostudies-arrayexpress
MetabolomicsComparative 1H-NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases associated with increased cardiovascular risk and metabolic alterations. We applied 1H-NMR spectroscopy to profile lipoproteins and metabolites in women with RA, SLE, and healthy controls. Both RA an...

2026-02-02 | MTBLS13820 | MetaboLights
TranscriptomicsLimited systemic sclerosis patients with PAH show biomarkers of inflammation and vascular injury
Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury Forty-nine PBMC samples were obtained from 21 lSSc subjects without PAH (lSSc-noPAH), 15 lSSc subjects with PAH (lSSc-PAH), and 10 healthy controls; three subjects provided P...
ORGANISM(S): Homo sapiens 
2010-10-27 | E-GEOD-19617 | biostudies-arrayexpress
TranscriptomicsStable gene expression of serial skin biopsies defines patient subsets in diffuse cutaneous systemic sclerosis
Systemic sclerosis (SSc) shows complex clinical manifestations including progressive skin and internal organ fibrosis. SSc can be divided into 'intrinsic subsets' by gene expression suggesting patient-specific heterogeneity in pathogenesis or temporal evolution of disease. Here we validate these su...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-32413 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblast isolated from either back or forearm punch biopsies from normal control patients, patients with a diagnosis of Systemic Sclerosis with Diffuse Scleroderma and patients with a diagnosis of morphea
Fibroblast were isolated from either back or forearm punch biopsies taken by Dr. Kari Connolly(UCSF) from either normal control patients, patients with a diagnosis of Systemic Sclerosis with Diffuse Scleroderma and patients with a diagnosis of morphea. Scleroderma fibroblast were grown to confluenc...
ORGANISM(S): Homo sapiens 
2005-10-19 | E-SMDB-2225 | biostudies-arrayexpress
TranscriptomicsSuppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis
Type I IFNs are implicated in the pathophysiology of systemic sclerosis (SSc). Recently, a Phase I open-label trial was conducted with an anti-IFNAR1 receptor antibody (anifrolumab) in adult SSc patients. In this study, we aim to assess the downstream effects of anifrolumab and elucidate the role of...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-65336 | biostudies-arrayexpress
TranscriptomicsSystemic and cell type-specific gene expression patterns in scleroderma skin
This SuperSeries is composed of the following subset Series: GSE3886: Scleroderma Morphea Normal Fibroblasts GSE3887: Scleroderma Architecture Cell Lines Abstract: We used DNA microarrays representing >12,000 human genes to characterize gene expression patterns in skin biopsies from individuals wit...
ORGANISM(S): Homo sapiens 
2006-03-07 | E-GEOD-4385 | biostudies-arrayexpress
ProteomicsUbiquitin Proteomics Analysis of Systemic Sclerosis Lung Fibroblasts with or without KLHL42 knockdown
Systemic scleroderma (SSc) is an autoimmune disease which results in fibrotic production in the lung. Resultant SSC-pulmonary fibrosis is the main cause of mortality among SSc patients. From high throughput RNAi screening, we uncovered the ubiquitin E3 ligase KLHL42 as a potential pro-fibrotic media...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-14 | MSV000084800 | MassIVE
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