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TranscriptomicsGenomic alterations and gene expression in primary diffuse large B cell lymphomas of immune privileged sites
Primary diffuse large B cell lymphomas of different immune-privileged sites (IP-DLBCL) share many clinical and biological features, such as a relatively poor prognosis, preferential dissemination to other immune-privileged sites and deletion of the HLA region, which suggests that IP-DLBCL represents...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-10524 | biostudies-arrayexpress
TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
TranscriptomicsCombined arrayCGH and SNP-loss of heterozygosity analysis in cervical cancer
BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygos...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-8605 | biostudies-arrayexpress
TranscriptomicsOncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome
Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is a malignancy of mature, skin-homing T cells. Sézary syndrome (Sz) is often considered to represent a leukemic phase of MF. In this study the pattern of numerical chromosomal alterations in MF tumor samples was defined usin...
ORGANISM(S): Homo sapiens 
2008-09-29 | E-GEOD-12902 | biostudies-arrayexpress
TranscriptomicsNovel and highly recurrent chromosomal alterations in Sézary syndrome
This study was designed to identify highly recurrent genetic alterations typical of Sézary syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing pathogenetic mechanisms and novel therapeutic targets. High-resolution array-based comparative genomic hybridization was don...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16384 | biostudies-arrayexpress
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