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MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
TranscriptomicsscRNA-seq characterisation of in vitro-generated CD8+ exhausted human T cells
scRNA-seq was performed to characterise an in vitro model of T cell exhaustion. CD8+ T cells from two donors underwent chronic stimulation to induce exhaustion and samples were collected from multiple points across the protocol to examine the subsets and transcriptional signatures present.
ORGANISM(S): Homo sapiens 
2026-05-31 | E-MTAB-15435 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsMolecular signature of CD8+ T cell exhaustion in metastases but not in peripheral blood from melanoma patients
In chronic viral infections such as HIV-1, HBV and HCV, CD8+ T cells may become M-bM-^@M-^]exhaustedM-bM-^@M-^], characterized by progressive functional deficiency. Recently, the underlying mechanisms have been characterized by molecular profiling of virus-specific CD8+ T cells. In contrast, only li...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-24536 | biostudies-arrayexpress
TranscriptomicsSingle cell TCR-seq of T cells isolated from MC38 mouse tumors
We investigate the single-cell landscape of the inflammatory mouse tumor model MC38, a C57BL/6 tumor cell line derived from colon adenocarcinoma. MC38 (diluted in HBSS and matrigel) was inoculated in the right unilateral flank (in the border of positions B2 and B3) of C57BL/6 mice (ref Study 16-3384...
ORGANISM(S): Mus musculus 
2019-05-11 | E-MTAB-7918 | biostudies-arrayexpress
ProteomicsMultiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming
T-cell exhaustion occurs when T cells are chronically activated, usually in the context of cancer or chronic infection. Exhausted T cells lose effector functions, upregulate inhibitory receptors, and lose proliferation ability. Understanding the mechanisms of T-cell exhaustion is important as it has...
ORGANISM(S): Homo sapiens (Human) 
2024-11-28 | PXD057703 | Pride
Human Phosphoproteomics Metabolomics T-cells Cd4+ Proteomics T-cell exhaustion 
MetabolomicsSystem Xc- exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma

OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...

2024-01-16 | MTBLS5358 | MetaboLights
ProteomicsPD-L1 overexpression, SWI/SNF complex Deregulation and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4+ T Cells
The growing tumor avoids recognition and destruction by immune system. During continuous stimulation of tumor infiltrating lymphocytes (TILs) by tumor, TILs become functionally exhausted. Thus, they become unable to kill tumor cells and to produce some cytokines, and lose their ability to proliferat...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-17 | PXD026447 | Pride
Cd4+ effector t cells  t cell exhaustion  swi/snf complex  pd-1  pd-l1  pd-l1/pd-1 axis 
TranscriptomicsTranscription profiling of human CD8 T cells in systemic lupus erythematosus (SLE) and vasculitis
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of the potentially toxic immunosuppressive therapy required for their control. Clinically useful biomarkers have been identified using DNA micr...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-157 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors
CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1)...
ORGANISM(S): Homo sapiens 
2010-10-03 | E-GEOD-24081 | biostudies-arrayexpress
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