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GenomicsGenome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3
Genome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3
PRJNA1481456 | ENA
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD019946 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-05 | PXD019947 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
TranscriptomicsHIV-Induced Sialoglycans on Infected CD4+ T Cells Promote Immune Evasion from Myeloid Cell-Mediated Killing
RNAseq profilling of monocytes co-cultured with HIV-TYBE infected primary CD4 T cells (E:T=10:1) in the presence of 10-1074, 10-1074-SiaD or Isotype antibody
ORGANISM(S): Homo sapiens 
2025-10-15 | E-MTAB-15808 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3, Mlkl, and Bid
Genome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3, Mlkl, and Bid
PRJNA1481243 | ENA
ProteomicsInhibition of TBK1/IKKe mediated RIPK1 phosphorylation sensitizes tumors to immune cell killing.
Resistance to immune cell-mediated cytotoxicity poses a significant challenge in cancer therapy, compromising the efficacy of immunotherapeutic approaches such as immune checkpoint blockade (ICB) treatment. To enhance therapy outcomes, it is crucial to identify interventions that can synergize with ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD062987 | Pride
Biotin ap Phosphorylation Tumors Tnf signaling Tbk1 Ripk1 
GenomicsA major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
PRJNA544340 | ENA
GenomicsA Major Chromatin Regulator Determines Resistance of Tumor Cells to T cell Mediated Killing
A Major Chromatin Regulator Determines Resistance of Tumor Cells to T cell Mediated Killing
PRJNA420997 | ENA
GenomicsCUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy
CUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy
PRJNA1170991 | ENA
GenomicsTSC2 regulates tumor susceptibility to TRAIL-mediated T cell killing by orchestrating mTOR signaling
TSC2 regulates tumor susceptibility to TRAIL-mediated T cell killing by orchestrating mTOR signaling
PRJNA832108 | ENA
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