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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsFunctional Analysis and Gene Expression Profile of Umbilical Cord Blood Regulatory T Cells
Since the role of cord blood (CB) regulatory T cells (Tregs) for the suppression of the allogeneic T-cell response is under investigation, we analyzed and compared the functional properties and gene expression profile of Tregs expanded from CB units or from the peripheral blood (PB) of helathy donor...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22501 | biostudies-arrayexpress
TranscriptomicsIFN-M-NM-3-induced iNOS expression in regulatory macrophages prolongs allograft graft survival in fully immunocompetent recipients.
Mouse monocytes exposed to M-CSF and IFN-M-NM-3 were driven to a suppressor phenotype over a seven day culture period. The resulting regulatory macrophages (M regs) expressed markers distinguishing them from M0-, M1-, and M2-polarised macrophages and monocyte-derived DCs. M regs completely suppresse...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-32690 | biostudies-arrayexpress
UnknownMassive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.
Not available
S-EPMC3551476 | biostudies-literature
TranscriptomicsTranscription profiling of human FoxP3+CD4+CD25+high regulatory T cells (Tregs) isolated from recent-onset type 1 diabetes mellitus (T1D) patients and controls
Naturally occurring FoxP3+CD4+CD25+high regulatory T cells (Tregs) play an important role in dominant tolerance, suppressing auto-reactive CD4+CD25- T cell activity. Although Tregs from T1D subjects are functionally deficient, there is little knowledge of the molecular mechanisms that orchestrate th...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-10586 | biostudies-arrayexpress
TranscriptomicsExpression data from regulatory T cells with Stat3 ablation
We used microarrays to detail the global programme of gene expression dependent upon Stat3 in regulatory T cells Regulatory T cells isolated from Foxp3 Stat3 or Foxp3 Stat3 were isolated using FACS based sorting followed by RNA extraction, amplification, labeling and...
ORGANISM(S): Mus musculus 
2009-09-04 | E-GEOD-17962 | biostudies-arrayexpress
TranscriptomicsFunctional Plasticity of Regulatory T Cell Function
Regulatory T cells (Tregs) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. While Tregs possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any inter-relationship orcross-regulatory mechani...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29262 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of miRNA in CD4+ T-cells from brain of EAE+Vehicle and EAE+DIM mice
C57BL/6 mice were immunized by subcutaneous injection of MOG35-55 peptide.DIM post-treatment was given at DAY 10 of the disease progression. CD4 T cells were isolated from the brain of the mice on day 15 of the MOG35-55 peptide immunization. Total RNA was extracted and subjected to microRNA high-...
ORGANISM(S): Mus musculus 
2013-11-01 | E-MTAB-2026 | biostudies-arrayexpress
UnknownThe common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Not available
S-EPMC11410371 | biostudies-literature
UnknownThe common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Not available
S-EPMC10602033 | biostudies-literature
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