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TranscriptomicsTranscription profiling of human VEGF-derived CD8+ T-cell epitope
The vascular endothelial growth factor A (VEGF) is involved in various physiological processes such as angiogenesis or wound healing but is also crucial in pathological events such as tumor growth. Thus, clinical anti-VEGF treatments have been developed which could already prove to have enormous ben...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-8050 | biostudies-arrayexpress
ModelsSanjuan2013 - Evolution of HIV T-cell epitope, control model
Sanjuan2013 - Evolution of HIV T-cell epitope, control model Control model in which the virus targets a nonimmune cell type C (e.g., hepatocytes, epithelial cells, etc.), instead of T H cells. This model is described in the article:...
2005-01-01 | MODEL1302180002 | BioModels
ModelsSanjuan2013 - Evolution of HIV T-cell epitope, immune activation model
Sanjuan2013 - Evolution of HIV T-cell epitope, immune activation model Model of cellular immune response against HIV. This model is described in the article: Immune activation promotes evolutionary conservation of T-cell epitopes ...
2005-01-01 | MODEL1302180001 | BioModels
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080779 | MassIVE
ProteomicsIntact Transition Epitope Mapping- Thermodynamic Weak-force Order (ITEM-TWO)
Most important characteristics of antibodies are that they typically strongly bind to specific epitopes, thereby expressing low dissociation constants (KDs) and high Gibbs free binding energies (delta Gs). In this study, we describe an off-line nano-electrospray mass spectrometry method, termed IT...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD016024 | Pride
Antibody affinity determination Antibody specificity determination 
TranscriptomicsSingle-cell gene expression analysis of in vitro expanded CD4 T cells responding to HHV-6B and HCMV epitopes
Assessment of the gene expression differences between HHV-6B-specific and HCMV-specific CD4 T cells at single-cell level. The peripheral blood mononuclear cells samples were collected from normal subjects expressing HLA-DRB1*03:01. The HHV-6B-specific or HCMV-specific T cells were expanded in vitro ...
ORGANISM(S): Homo sapiens 
2025-11-21 | E-MTAB-16174 | biostudies-arrayexpress
TranscriptomicsExpression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection
CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transf...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress
TranscriptomicsRole of TCR:peptide/MHC Class I Affinity in Directing Different Maturation Phenotypes of Dominant and Subdominant Epitope-Specific CD8+ T Cells in Mamu-A*01+ Rhesus Monkeys
CD8+ T cells that bind different regions of proteins derived from a virus are often present at different frequencies. It is thought that those virus-specific CD8+ T cells that are present at the highest frequency are predominantly responsible for control of viral infections. While the number of viru...
ORGANISM(S): Macaca mulatta 
2014-04-24 | E-GEOD-54001 | biostudies-arrayexpress
Genomics­­Rapid TCR:Epitope Ranker (RAPTER): A primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution
­­Rapid TCR:Epitope Ranker (RAPTER): A primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution
PRJNA970348 | ENA
ProteomicsMutations in epitope flanking regions for SARS-CoV-2 nucleoprotein affect proteasomal processing to alter CD8+ T cell responses
Viral CD8+ epitopes are generated by the cellular turnover of viral proteins, predominantly by the proteasome1. Mutations located within viral epitopes can result in escape from memory T cells2. Focussing on two of the most dominant SARS-CoV-2 nucleoprotein CD8+ epitopes3,4, we identified mutations ...
ORGANISM(S): recombinant SARS coronavirus 
2023-10-24 | PXD032054 | Pride
Lc-ms/ms Sars-cov-2 T-cell Antigen Epitope 
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