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TranscriptomicsT cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Although transcriptional programs associated with T-cell specification and commitment have been described, the functional hierarchy and the roles of key regulators in structuring/ orchestrating these programs remain unclear. Activation of Notch signaling in uncommitted precursors by the thymic strom...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-33513 | biostudies-arrayexpress
TranscriptomicsTCF1 is required for the differentiation of T follicular helper (TFH) cells during viral infections
TFH and Th1 cells generated after viral or intracellular bacterial infections are critical for the control of infections and the development of immunological memories. However, the mechanisms that govern the choice of activated CD4 T cells to the two alternative fates remain unclear. Here, we found ...
ORGANISM(S): Mus musculus 
2015-09-18 | E-GEOD-65660 | biostudies-arrayexpress
TranscriptomicsExpression data from Tcf1 deficient and Tcf1 wildtype cultured bone marrow lymphoid primed progenitors after four days on Notch ligand expressing stroma (OP9-DL4).
Tcf1 is necessary for optimal T lineage development. Tcf1 deficient progenitors fail to initiate the T lineage program in vitro and development is severely defective in vivo. We used microarrays to assess the overal global gene expression differences from Tcf1 wildtype and deficient lymphoid biased ...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-26559 | biostudies-arrayexpress
TranscriptomicsMemory-like CD8 T-cells sustain the immune response to chronic viral infections.
We have discovered a small subpopulation of virus-specific CD8 T-cells that sustains the T-cell response in chronic infections. These cells are defined by - and depend on - the expression of the transcription factor Tcf1 (T cell factor 1) and show key characteristics of central memory cells while ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-83978 | biostudies-arrayexpress
GenomicsImpact of Tcf1 and Lef1 deficiency on histone marks and Tcf1 binding in CD8 T cells
Comparison of epigenome and Tcf1 occupancy between control and Tcf1/Lef1-deficient CD8 T cells Control mice or those are deficient for Tcf1 and Lef1 transcription factors (deleted by CD4-Cre) were used to isolate thymocytes. The thymocytes were surface-stained to identify TCRbeta high, CD69–, CD24...
ORGANISM(S): Mus musculus 
2016-02-12 | E-GEOD-73239 | biostudies-arrayexpress
ProteomicsInverted chromatin immunoprecipitation identifies Tcf1 as a negative regulator of Foxp3 expression
Regulatory T (Treg) cells are important regulators of the immune system and have versatile functions for the homeostasis and repair of tissues. They express the forkhead box transcription factor Foxp3 as a lineage-defining protein. In mature Treg cells, the Foxp3 core promoter is unmethylated indica...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018764 | Pride
T-cell factor 1 (tcf1) Foxp3-promoter Regulatory t (treg) cells 
TranscriptomicsExpression data from Tcf1-expressing Thy1+CD25+ T lineage cells
We used microarrays to perform a global gene expression analysis in Tcf1-expressing Thy1+CD25+ T lineage cells that develop on OP9 stroma in the absence of Notch1 signals. We compare this to the starting population, LMPP progenitors, and to control expressing T lineage cells that developed on OP9 st...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-26560 | biostudies-arrayexpress
TranscriptomicsExpression data from WT DN3, TCF-1-deficient DN3 thymocytes, and T cell lymphomas in TCF-1-deficient animals.
TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-33292 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and TCF-1-deficient memory CD8 T cells
TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
TranscriptomicsGene expression in thymi of Tcf1 -/-, Tcf +/- or Tcf1 -/- mice with tumor.
The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1-/- mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks i...
ORGANISM(S): Mus musculus 
2014-02-14 | E-GEOD-54976 | biostudies-arrayexpress
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