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ProteomicsAnticodon loop remodeling and D-stem shape drive the specific recognition of ANN-decoding tRNAs for t6A modification
N6-threonylcarbamoyladenosine (t6A) is a universal tRNA modification essential for translational fidelity. The modification is installed at position 37 of ANN-decoding tRNAs (N is A, U, G or C) by transfer of a threonylcarbamoyl moiety from a pathway intermediate, catalyzed in bacteria by the TsaBD ...
ORGANISM(S): Escherichia coli 
2026-05-28 | PXD071262 | Pride
Cryo-em Trna Tsab2d2 T6a 
TranscriptomicsGlobal Translational Impacts of the Loss of the tRNA Modification t6A in Yeast
The universal tRNA modification t6A is found at position 37 of nearly all tRNAs decoding ANN codons. The importance of t6A in decoding has been studied for the past 40 years, but the cellular role has remained unclear. In this work, we examined the genome-wide effect to translation during the absenc...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-15 | E-GEOD-72030 | biostudies-arrayexpress
Genomicst6A tRNA modification defines RIG-I mediated anti-tumour immune response [RNA-seq2]
t6A tRNA modification defines RIG-I mediated anti-tumour immune response [RNA-seq2]
PRJNA1209981 | ENA
Genomicst6A tRNA modification defines RIG-I mediated anti-tumour immune response [RNA-seq1]
t6A tRNA modification defines RIG-I mediated anti-tumour immune response [RNA-seq1]
PRJNA1209978 | ENA
Genomicst6A tRNA modification defines RIG-I mediated anti-tumour [Ribo-seq] immune response
t6A tRNA modification defines RIG-I mediated anti-tumour [Ribo-seq] immune response
PRJNA1209976 | ENA
TranscriptomicsGlobal Translational Impacts of the Loss of the tRNA Modification t6A in Yeast
The universal tRNA modification t6A is found at position 37 of nearly all tRNAs decoding ANN codons. The importance of t6A in decoding has been studied for the past 40 years, but the cellular role has remained unclear. In this work, we examined the genome-wide effect to translation during the absenc...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-15 | GSE72030 | GEO
UnknownStructure and mechanism of a bacterial t6A biosynthesis system.
Not available
S-EPMC5814804 | biostudies-literature
UnknownMolecular basis for t6A modification in human mitochondria.
Not available
S-EPMC7102964 | biostudies-literature
UnknownConformational communication mediates the reset step in t6A biosynthesis.
Not available
S-EPMC6614819 | biostudies-literature
UnknownCommonality and diversity in tRNA substrate recognition in t6A biogenesis by eukaryotic KEOPSs.
Not available
S-EPMC8887486 | biostudies-literature
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