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TranscriptomicsTranscription profiling of mouse dorsal aorta derived mesangioblast clone comparison
Mouse dorsal aorta from E9.5 mouse embryos (C57BL6) was grown as an explant culture as described elsewhere (De Angelis et al., 1999). After 5 days the explant was dissociated into a single cell suspension, and plated at limiting dilution on a feeder layer of Mitomycin C-treated primary embryonic mou...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-552 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cells treated with different growth factors
The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of skeletal ("mesenchymal") stem cells (SSCs) found in BM stroma, have long remained elusive. We show that MCAM/CD146-expressing, subendothelial cells in human BM stroma are both the self-ren...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6460 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD14-myeloblasts
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21943 | biostudies-arrayexpress
TranscriptomicsNormal counterpart in the identification of a molecular signature for leukemic promyelocytes
Gene expression profiles of 8 samples of CD34+derived normal promyelocytes We collected RNA from CD34+cells from healthy blood donors cultured in serum-free medium with G-CSF, IL-3 and GM-CSF
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64282 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD34+ progenitor cells
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progeni...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-13110 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human iPS cell-derived mesoangioblasts (HIDEMs)
Mesoangioblasts are stem/progenitor cells derived from a subset of pericytes expressing alkaline phosphatase. They have been shown to ameliorate muscular dystrophies (currently incurable diseases) in different animal models and are now undergoing clinical experimentation for Duchenne muscular dystro...
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-36098 | biostudies-arrayexpress
TranscriptomicsChanges of miRNA expression in granulocytes of patients with polycythemia vera (PV) and essential thrombocythemia (ET) receiving INCB018424 in a Phase 2 study
A global microRNA expression profile was obtained from gradient-purified granulocytes (>95% pure) collected at the time of screening and at cycle 4 of treatment Protocol #18424-256 is a Phase 2 study of the JAK1 and JAK2 inhibitor INCB01842 in patients with advanced polycythemia vera (PV) and essent...
ORGANISM(S): Homo sapiens 
2012-09-26 | E-GEOD-32194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human eessential thrombocythemia megakaryocytes versus normal megakaryocytes
Normal donors BM CD34+ cells were differentiated in thrombopoietin-treated liquid suspension cultures. Briefly, CD34+ cells (80,000 /mL) were resuspended in a serum-free medium in the presence of 100 ng/mL of human recombinant thrombopoietin (TPO; Genzyme, Boston, MA). Every 3 days, viable cells wer...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-997 | biostudies-arrayexpress
TranscriptomicsNo identical 'mesenchymal stem cells' at different times and sites: Human committed progenitors of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels
A widely shared view reads that 'MSCs' are ubiquitous in human connective tissues, can be defined by a common in vitro phenotype, share a skeletogenic potential as assessed by in vitro differentiation assays, and coincide with the ubiquitous 'pericytes.' Using stringent in vivo differentiation assay...
ORGANISM(S): Homo sapiens 
2016-06-02 | E-GEOD-69991 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mutated and wild-type PMF CD34+ cells
Primary mielofibrosis (PMF) is a rare chronic myeloproliferative disorder characterized by the accumulation of abnormal megakaryocytes (Mks) in the bone marrow (BM), variable degrees of BM fibrosis, osteosclerosis and angiogenesis, immature myeloid and erythroid cells, and tear-drop erythrocytes in ...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-41812 | biostudies-arrayexpress
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