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UnknownDesign, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors.
Not available
S-EPMC5554898 | biostudies-literature
ProteomicsSecreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dysregulated immune activation. Emerging evidence indicates that resident and infiltrating immune cells...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD069220 | Pride
Sars-cov-2  orf8  macrophage  ace2  pyroptosis  il-1β  brodalumab 
UnknownDiscovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo.
Not available
S-EPMC12632963 | biostudies-literature
UnknownDiscovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo.
Not available
S-EPMC12788873 | biostudies-literature
ProteomicsSelective RNA sequestration in P-bodies regulates cell identity
Post-transcriptional regulation is pivotal in guiding the gene expression programs that instruct cell fate decisions. Recent studies emphasize the significance of biomolecular condensates in modulating gene expression through RNA processing and translational control. However, the functional roles of...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058827 | Pride
P-bodies Proteomics Stem cells 
UnknownViral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
Not available
S-EPMC9234021 | biostudies-literature
UnknownNeutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.
Not available
S-EPMC11349990 | biostudies-literature
ProteomicsPhosphoproteomics of Natural Killer (NK) Cells Stimulated with Fibrin and IL-15
Phosphoproteomic analysis of fibrin or IL-15 treated NK cells with timsTOF HT
ORGANISM(S): Homo sapiens (Human) 
2024-06-26 | PXD049692 | Pride
Timstof ht Nk cells Phoshoproteomics 
UnknownNeutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination.
Not available
S-EPMC9309042 | biostudies-literature
UnknownThe Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.
Not available
S-EPMC12629595 | biostudies-literature
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