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GenomicsGenomic binding profile of TAL1 in human Endothelial Colony-Forming Cells
Endothelial colony-forming cells (ECFCs) have been reported as promising cells for regenerative medicine thanks to their angiorepair properties. Transcription factors are primary determinants of the functional capacity of the cells and TAL1 has been shown as a critical regulator of endothelial linea...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-44442 | biostudies-arrayexpress
TranscriptomicsshRNA mediated knock-down of Tal1 in human Endothelial Colony Forming Cells (ECFCs)
Endothelial colony-forming cells (ECFCs) have been reported as promising cells for regenerative medicine thanks to their angiorepair properties. Transcription factors are primary determinants of the functional capacity of the cells and TAL1 has been shown as a critical regulator of endothelial linea...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-44444 | biostudies-arrayexpress
GenomicsComparative analysis of TAL1 binding in TSA-treated versus non-treated Endothelial Colony Forming Cells (ECFCs)
Endothelial progenitors represent one of the most promising cell-based strategies for vascular repair of ischemic tissue damage, including limb ischemia, myocardial infarction and stroke. We have shown that the transcription factor TAL1 regulates a transcription program that drives the migration and...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-53423 | biostudies-arrayexpress
GenomicsCore transcriptional regulatory circuit controlled by the tal1 complex in human t-cell acute lymphoblastic leukemia (Subseries)
The oncogenic transcription factor TAL1/SCL is aberrantly overexpressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing the importance of the TAL1-regulated transcriptional program in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regu...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-33850 | biostudies-arrayexpress
ProteomicsThe transcription factor TAL1 and the miR-17-92 cluster establish a regulatory loop
A network of gene regulatory factors such as transcription factors and microRNAs establish and maintain the gene expression pattern during hematopoiesis. In this network transcription factors regulate each other and are involved in regulatory loops with microRNAs.The microRNA cluster miR-17-92 is lo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018052 | Pride
Human Microrna Blood Tal1 Jurkat cells Mir-17-92 Hematopoiesis 
GenomicsDifferential genomic targeting of the transcription factor TAL1 in alternate hematopoietic lineages
TAL1/SCL is a master regulator of hematopoiesis whose expression promotes opposite outcomes depending on the cell type - differentiation in the erythroid lineage or oncogenesis in the T-cell lineage. Here we used a combination of ChIP-sequencing and gene expression profiling to compare the function ...
ORGANISM(S): Homo sapiens 
2010-10-30 | E-GEOD-25000 | biostudies-arrayexpress
GenomicsGenome-wide binding of GATA1 and TAL1 determined at high resolution
Erythroid development and differentiation from multiprogenitor cells to red blood cells requires precise transcriptional regulation. Key erythroid transcription factors, GATA1 and TAL1, co-operate, along with other proteins, to regulate many aspects of this process. How GATA1 and TAL1 are positional...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-68964 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of Tal1 knockout chimeric mouse embryos at embryonic day 8.5 of mouse development
Chimeric embryos were generated to investigate the effect of Tal1 knockout in mouse embryos by single-cell RNA-sequencing. Tal1 is an essential transcription factor for the formation of the embryonic blood. Embryo chimerism permits the analysis of the effects of Tal1 knockout without the confounding...
ORGANISM(S): Mus musculus 
2018-12-05 | E-MTAB-7325 | biostudies-arrayexpress
GenomicsLdb1-nucleated transcription complexes function as primary mediators of erythroid gene activation
We used ChIP-Seq to map Ldb1, Scl and Gata1 binding sites in mouse total bone marrow cells. Together with functional studies comparing gene expression in Murine Erythroleukemia (MEL) cells expressing Ldb1 shRNA or control shRNA and bioinformatics analysis, we systematically determined the transcrip...
ORGANISM(S): Mus musculus 
2013-04-29 | E-GEOD-42843 | biostudies-arrayexpress
GenomicsThe Transcriptional Programme Controlled by Scl/Tal1 Gene during Early Embryonic Haematopoietic Development
The basic-helix-loop-helix transcription factor Scl/Tal1 controls the development and subsequent differentiation of haematopoietic stem cells (HSCs). However, since few Scl target genes have been validated to date, the underlying mechanisms have remained largely unknown. Here we have employed ChIP...
ORGANISM(S): Mus musculus 
2009-06-19 | E-GEOD-15806 | biostudies-arrayexpress
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