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TranscriptomicsComparative in situ gene expression profile of starry-sky tumor-associated macrophages and germinal centre macrophages
Cells undergoing apoptosis are known to modulate their tissue microenvironments. By acting on phagocytes, notably macrophages, apoptotic cells inhibit immunological and inflammatory responses and promote trophic signaling pathways. Paradoxically because of their potential to cause death of tumor cel...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64366 | biostudies-arrayexpress
TranscriptomicsSynergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
Tumor-associated macrophages (TAMs) represent alternatively activated (M2) macrophages that support tumor growth. Previously, we have described a special LYVE-1(+) M2 TAM subset in vitro and in vivo; gene profiling of this TAM subset identified MS4A8A as a novel TAM molecule expressed in vivo by TAM...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-38171 | biostudies-arrayexpress
TranscriptomicsSynergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A
Analysis of bone marrow derived macrophages (BMDM) incubated with dexamethasone&IL4 (Dexa+IL4), B16F1 tumor conditioned medium (cmB16), and B16F1 tumor conditioned medium supplemented with dexamethasone&IL4 (cmB16+dexa+IL4). Results allow detection of genes that require synergistic stimulation of tu...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-25707 | biostudies-arrayexpress
ProteomicsProfiling of antibodies against prostate cancer xenograft-released proteins
The present study describes a novel xenograft-based biomarker discovery platform and proves its usefulness in the discovery of novel serum markers for prostate cancer (PCa). By immunizing immuno-competent mice with serum from nude mice bearing PCa xenografts, an antibody response against xenograft-d...
ORGANISM(S): Mus musculus 
2011-12-16 | E-GEOD-16220 | biostudies-arrayexpress
UnknownPGRN inhibits CD8+T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM.
Not available
S-EPMC10981592 | biostudies-literature
UnknownProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality.
Not available
S-EPMC12269690 | biostudies-literature
TranscriptomicsATP2A2 and miRNA in human myocardial infarction
Cardiac sarco(endo)plasmic reticulum calcium ATPase-2 (SERCA2) plays one of the central roles in myocardial contractility. Both, SERCA2 mRNA and protein are reduced in myocardial infarction (MI), but the correlation has not been always observed. MicroRNAs (miRNAs) act by targeting 3'-UTR mRNA, causi...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-17304 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis for Pch/ Ler regulon in enterohaemorrhagic Escherichia coli O157:H7
Enterohaemorrhagic Escherichia coli (EHEC) is an emerging pathogen that causes diarrhea and heamolytic uremic syndrome. Much of the genomic information that affects virulence is acquired via horizontal transfer. Genes necessary for attaching and effacing lesions are located in the LEE pathogenicity ...
ORGANISM(S): Escherichia coli O157:H7 str. Sakai 
2010-05-26 | E-GEOD-9752 | biostudies-arrayexpress
GenomicsSpecificity, propagation and memory of pericentric heterochromatin in mouse fibroblasts
We assembled a quantitative map for the abundance and interactions of 16 factors related to PCH in living cells and found that stably bound complexes of the histone methyltransferase Suv39h1/2 demarcate the PCH state. From the experimental data we developed a predictive mathematical model that expla...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-58555 | biostudies-arrayexpress
UnknownEffects of High-Intensity Interval Training and Isoinertial Training on Leg Extensors Muscle Function, Structure, and Intermuscular Adipose Tissue in Older Adults.
Not available
S-EPMC6794371 | biostudies-literature
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