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ProteomicsProteomic profiling of AML patient-derived xenografts across serial transplantation
This dataset contains mass spectrometry-based proteomic profiling of acute myeloid leukemia patient-derived xenograft samples collected across serial transplantation stages. The study aimed to characterize proteome remodeling associated with leukemia propagation and disease evolution in AML PDX mode...
ORGANISM(S): Homo sapiens (Human) 
2026-07-20 | PXD078079 | Pride
Acute myeloid leukemia  aml  patient-derived xenograft  pdx  serial transplantation  proteomics  mass spectrometry  leukemia stem cells 
ProteomicsHuman acute myeloid leukemia (AML) cell line LFQ, comparison between doxycycline-inducible control shRNA and Pim2 shRNA
Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20-30% of AML cases. This subtype usually responds poorly to conventional therapies including FLT3 tyrosine kinase inhibitors (TKIs) due to molecular bypass mechanisms. New therapeutic strategies are t...
ORGANISM(S): Homo sapiens (Human) 
2017-09-18 | PXD005880 | Pride
Aml Rna interference Pim2 Lfq 
TranscriptomicsMutations in RAS pathway induce synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia
Bulk RNAseq of primary AML samples at diagnosis
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10048 | biostudies-arrayexpress
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