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ProteomicsStructural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity
The coordination of cellular signaling networks with metabolic response is key for balanced energy production and homeostasis. This coordination is achieved through spatiotemporal control of metabolism via compartmentalization and redundancies coupled to rapid signaling. Such dynamics must therefore...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-17 | PXD054497 | Pride
Phosphoproteomics Metabolomics Metabolism Lc-ms Cell signaling Obesity 
ProteomicsTargeted exercise enhances functional integration of engineered muscle grafts after volumetric muscle loss
Damage that affects large volumes of skeletal muscle tissue can severely impact health, mobility, and quality-of-life. Efforts to restore muscle function by implanting engineered grafts at the site of damage have demonstrated limited restoration of force production. Various forms of mechanical and b...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039237 | Pride
Engineered muscle graft Muscle phosphoproteomics Volumetric muscle loss 
ProteomicsPhosphoproteomic Changes Induced by Cell-Derived Matrix and Their Effect on Tumor Cell Migration and Cytoskeleton Remodeling
Increased fibrotic extracellular matrix (ECM) deposition promotes tumor invasion, the first step of the metastatic cascade. Yet, the underlying mechanisms are poorly understood as conventional studies of tumor cell migration are often performed in 2D culture lacking the compositional and structural ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044029 | Pride
Cytoskeleton Lyn signaling Adhesion Migration Phosphoproteomics Extracellular matrix 
ProteomicsParallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome
Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved post-translational modification that facilitates rapid and reversible modulation of enzyme activity, localization or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in h...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD052217 | Pride
Metabolomics Egf signaling Phosphoprotoemics Tyrosine phosphorylation 
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