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TranscriptomicsLigand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63202 | biostudies-arrayexpress
TranscriptomicsTanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [human]
Purpose: To explore the mechanism of how Tan I inhibits malignant hematopoiesis at the gene expression level Methods: NB4 cells treated with DMSO or Tan I 10 μM were collected for RNA sequencing Results: We found that 376 genes were differentially expressed between DMSO and Tan I treatment in the NB...
ORGANISM(S): Homo sapiens 
2020-08-04 | GSE155572 | GEO
GenomicsTanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [human]
Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [human]
PRJNA650378 | ENA
TranscriptomicsTanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [zebrafish]
Purpose: To explore the mechanism of how Tan I inhibits malignant hematopoiesis at the gene expression level Methods: 72 hpf Tg(c-mybhyper: GFP) zebrafish embryos treated with DMSO or Tan I 60 μM were collected for RNA sequencing Results: We found that 1882 genes were differentially expressed betwee...
ORGANISM(S): Danio rerio 
2020-08-04 | GSE155573 | GEO
ProteomicsLC-MS anallysis of immunoprecipitated HLA class I antigen, Tan
Qualitative LC-MS analysis of test vs control IP of HLA class I antigen samples.
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD051193 | Pride
Ip Lcms Label free 
GenomicsTanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [zebrafish]
Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [zebrafish]
PRJNA650379 | ENA
TranscriptomicsTranscriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable of augmenting tumor growth. However, little is kno...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-43254 | biostudies-arrayexpress
UnknownNatural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer.
Not available
S-EPMC7333144 | biostudies-literature
UnknownPleiotropic Effects of ebony and tan on Pigmentation and Cuticular Hydrocarbon Composition in Drosophila melanogaster.
Not available
S-EPMC6504824 | biostudies-literature
TranscriptomicsTranscriptome analysis reveals the molecular regulatory network of dietary supplementation with succinate on muscle fiber characteristics and meat quality in Tan sheep
To investigate the impact of adding succinate to the diet on the production performance, meat quality, muscle fiber characteristics, and transcriptome of the longissimus dorsi muscle in Tan sheep, 36 Tan sheep were selected and fed with different levels of succinate (0%, 0.5%, 1.0%, 2.0%) for a 60-d...
ORGANISM(S): Ovis aries 
2023-11-26 | GSE248353 | GEO
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