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ProteomicsProfiling the stress-dependent ubiquitinome of HEK293T cells via TUBE-capture and spectral counting proteomics
Here we investigate changes to the ubiquitin conjugation profile in response to various types of cellular stress. Ubiquitinated proteins from HEK293T cells following stress treatments and compared to those in unstressed cells using TUBE-affinity captured and MS-spectral counting analysis. This work ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD069603 | Pride
Ubiquitin Cellular stress Tandem ubiquitin binding entities (tube) 
ProteomicsProteomic Analysis of Ubiquitin Chain Types in Murine Cells and Tissues
Mass spectrometry-based proteomics has become an integral approach for characterising ubiquitin chain-linkage compositions and architectures. In this study, we optimised sample preparation and chromatographic separation of Ubiquitin peptides for Absolute Quantification by Parallel Reaction Monitorin...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-28 | PXD017754 | Pride
Absolute quantification Ubiquitin chain-linkage composition Murine tissues Parallel reaction monitoring 
ProteomicsProximal proteome and ubiquitination landscape of E3 Ubiquitin Ligase Mindbomb 1
To characterize the proximal proteome of Mindbomb 1 (MIB1) during adenovirus (AdV) infection ?we performed proximity labeling. MIB1 KO cell lines generated in the Hap1 cell line were stably reconstituted with either WT MIB1-APEX2, the MIB1 ubiquitination-defective mutant C985S-APEX2 or APEX2-mKate. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020542 | Pride
Apex2 Adenovirus Mindbomb 1 Lfq Tubes 
ProteomicsK48 ubiquitin selectively targets oxidized proteins in vivo
Ubiquitin is a highly conserved eukaryotic protein responsible for regulating a variety of functions when conjugated to target proteins. Ubiquitin is essential, accumulates during the stress response, and is the canonical signal for protein degradation by the proteasome. Still, the function of ubiqu...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-30 | PXD014173 | Pride
K48 ubiquitin Yeast Oxidation Oxidative stress 
UnknownThe GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Not available
S-EPMC8386601 | biostudies-literature
ProteomicsThe global Proteome and Ubiquitinome of bacterial and viral co-infected Bronchial Epithelial Cells
Viral infections facilitate bacterial trafficking to the lower respiratory tract resulting in bacterial viral co infections. Bacterial dissemination to the lower respiratory tract is enhanced by influenza A virus induced epithelial cell damage and dysregulation of immune responses. Epithelial cells ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD025146 | Pride
16hbe Proteomics Co infection Streptococcus pyogenes Staphylococcus aureus Ubiquitin Influenza a virus 
UnknownMass spectrometry analysis of K63-ubiquitinated targets in response to oxidative stress.
Not available
S-EPMC4510443 | biostudies-literature
ProteomicsK63 polyubiquitination is a new modulator of the oxidative stress response, shotgun data
Ubiquitination is a post-translational modification that signals multiple processes, including protein degradation, trafficking and DNA repair. Polyubiquitin accumulates globally during the oxidative stress response, and this has been mainly attributed to increased ubiquitin conjugation and perturba...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-01-26 | PXD000960 | Pride
K63 ubiquitination yeast oxidative stress 
MetabolomicsA Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.

BACKGROUND & AIMS: Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on pu...

2024-10-18 | MTBLS3476 | MetaboLights
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