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TranscriptomicsTranscription profiling of all major organ systems of Medicago truncatula to create a gene expression atlas
Medicago truncatula, which has a relatively small diploid genome, has been adopted as a model species for legume genomics. To enhance its value as a model, we have generated a gene expression atlas that provides a global view of gene expression in all major organ systems of this species, with speci...
ORGANISM(S): Medicago truncatula 
2008-03-15 | E-MEXP-1097 | biostudies-arrayexpress
MetabolomicsLipopolysaccharides from Ralstonia solanacearum induce a broad metabolomic response in Solanum lycopersicum

Ralstonia solanacearum, one of the most destructive crop pathogens worldwide, causes bacterial wilt disease in a wide range of host plants. The major component of the outer membrane of Gram-negative bacteria, lipopolysaccharides (LPS), has been shown to function as elicitors of plant defense lead...

2023-08-08 | MTBLS7324 | MetaboLights
TranscriptomicsDNA-damage induced differentiation of leukemic cells as an anti-cancer barrier
Here we show that the histone methyltransferase MLL4 (Kmt2d) is required for stem cell activity and an aggressive form of acute myeloid leukemia (AML) harboring the MLL-AF9 oncogene. MLL4 exerts its function by regulating transcriptional programs associated with the anti-oxidant response. The role o...
ORGANISM(S): Mus musculus 
2014-07-22 | E-GEOD-57147 | biostudies-arrayexpress
TranscriptomicsGraphene Oxide Substrate Promotes Neurotrophic Factor Secretion and Survival of Human Schwann-Like Adipose Mesenchymal Stromal Cells - RNAseq
Mesenchymal stromal cells from adipose tissue (AD-MSCs) exhibit favourable clinical traits for autologous transplantation and can develop a ‘Schwann-like’ phenotype (sAD-MSCs) to improve peripheral nerve regeneration, where severe injuries yield insufficient recovery. However, sAD-MSCs regress witho...
ORGANISM(S): Homo sapiens 
2021-03-08 | E-MTAB-10078 | biostudies-arrayexpress
MetabolomicsLipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia
Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from142 patients with CAP (CAP...
2016-08-11 | MTBLS354 | MetaboLights
TranscriptomicsThe Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-04 | E-GEOD-38601 | biostudies-arrayexpress
TranscriptomicsSIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human mesenchymal stem cells. RNAs isolated from SIRT6+/+ and SIRT6-/- hMSCs at early and late passages were sequenced, respectively. And, H3K4me3 ChIP-seq was performed upon the SIRT6 deleted hMSC an...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-64642 | biostudies-arrayexpress
UnknownAssessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.
Not available
S-EPMC6113773 | biostudies-literature
GenomicsPHB Acts as a Member of the HIRA Complex to Control an Epigenetic and Metabolic Circuitry
Cellular metabolism and chromatin landscape both contribute to cell fate determination. However, their interplay remains poorly understood. Here we show that Prohibitin (PHB), an evolutionarily conserved protein, involves in a histone variant H3.3 chaperon HIRA complex-dependent epigenetic and metab...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-72143 | biostudies-arrayexpress
UnknownSEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations.
Not available
S-EPMC11686012 | biostudies-literature
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