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MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicstRNA-m1A Methylation Regulates the Infection of Magnaporthe oryzae by Supporting Ergosterol Biosynthesis
Ergosterols are essential components of fungal plasma membranes. Inhibitors targeting ergosterol biosynthesis (ERG) genes are critical for controlling fungal pathogens, including Magnaporthe oryzae, the fungus that causes rice blast. In this study we show that the Trm6/Trm61 complex catalyzes dynami...
ORGANISM(S): Pyricularia Oryzae 70-15 
PXD051352 |
ProteomicsTailoring an Intravenously Injectable Oncolytic Virus for Augmenting Radiotherapy
Oncolytic viruses (OVs) combined with radiotherapy (RT) have shown promise in clinical trials but remain limited by unsatisfactory efficacy. Key challenges include poor intravenous delivery, insufficient RT-induced DNA damage, and suboptimal anti-tumor immune responses. Herein, we developed a novel ...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-02-02 | PXD060493 |
ProteomicsThe Shigella kinase effector OspG hijacks host ubiquitin signaling to escape septin-cage entrapment
We show by unbiased phosphoproteomics that a major target of OspG is CAND1, a regulatory protein controlling the assembly of cullin-RING ubiquitin ligases (CRLs). CAND1 phosphorylation weakens its interaction with cullins, which is expected to impact a large panel of CRL E3s. Indeed, global ubiquito...
ORGANISM(S): Homo Sapiens 
2024-01-10 | PXD048447 |
ProteomicsEndothelial FGF13 impairs angiogenesis by accelerating oxygen-independent HIF-1α degradation
Anti-Flag antibody was added to the lysate of HUVECs transfected with Flag-FGF13 for co-immunoprecipitation, and IgG was used as a negative control. LC-MS/MS analysis was carried out by PTM Bio Co., Ltd (Zhejiang, China). The substrate proteins that may bind to FGF13 were screened out according to t...
ORGANISM(S): Homo Sapiens 
PXD079802 |
ProteomicsPlasma proteomic profiling discovers molecular features associated with upper urinary tract urothelial carcinoma
Upper tract urothelial carcinoma (UTUC) is often diagnosed late and exhibits poor prognosis. Only limited data are available concerning potential noninvasive biomarkers for disease monitoring. Here, we investigated the proteomic profile of plasma in 362 UTUC patients and 239 healthy control samples....
ORGANISM(S): Homo Sapiens 
2023-07-12 | PXD043774 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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