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ProteomicsXAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence
XAB2 is a multi-functional protein participating processes including transcription, splicing, DNA repair and mRNA export. Here we report POLR2A as a major target gene down-regulated after XAB2 depletion. XAB2 depletion led to severe splicing defects of POLR2A with significant intron retention. Such ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012552 | Pride
Xab2 Polr2a Hela cell 
ProteomicsMouse cortex immunoprecipitation-mass spectrometry
To determine the mechanism for how Kctd10 deficiency impacts brain development, co-immunoprecipitation (co-IP) was performed to identify KCTD10-interacting proteins from the E14.5 cerebral cortex using a KCTD10 antibody, followed by mass spectrometric analysis. In total, 143 proteins uniquely precip...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD050135 | Pride
E14.5 Mouse Kctd10 Crebral cortex 
ProteomicsSerum LC-MSMS in patient of ischemic stroke
Based on activities of daily living assessments at admission and followed by a 3-month recovery, ischemic stroke participants were categorized into the groups involving the recovery of little effective (LE) and obvious effective (OE). Differentially expressed proteins (DEPs) derived from proteomic t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD052579 | Pride
Human serum Ischemic stroke rehabilitation 
UnknownDynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.
Not available
S-EPMC4850424 | biostudies-literature
ProteomicsIntegrated proteome and malonylome analyses reveal the potential meaning of TLN1 and ACTB in end-stage renal disease
Purpose: End-stage renal disease (ESRD) is a condition that is characterized by the loss of kidney function. ESRD patients suffer from various endothelial dysfunctions, inflammation, and immune system defects. Lysine malonylation (Kmal) is a recently discovered post-translational modification (PTM)....
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035147 | Pride
Lysine malonylation (kmal) Platelet activation Post-translational modification (ptm) End-stage renal disease (esrd) Chronic kidney disease (ckd) 
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