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ProteomicsXAB2 involved in RNA processing.
RNA splicing and the DNA damage response are intriguingly linked in mammals but the underlying mechanisms remain poorly understood. Using an in vivo biotinylation tagging approach in mice we show that XAB2, the human homologue of the yeast pre-mRNA-splicing factor SYF1 has a functional role in Nucle...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD014084 | Pride
Snrnas Xab2 Rna processing In vivo biotinylation Interaction analysis Pre-mrnas Nucleotide excision repair 
ProteomicsXAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence
XAB2 is a multi-functional protein participating processes including transcription, splicing, DNA repair and mRNA export. Here we report POLR2A as a major target gene down-regulated after XAB2 depletion. XAB2 depletion led to severe splicing defects of POLR2A with significant intron retention. Such ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012552 | Pride
Xab2 Polr2a Hela cell 
TranscriptomicsThe impact of XAB2 on gene expression and pre-mRNA splicing
Xab2 knock down followed by RNA-sequencing of oligo-dT selected transcripts
ORGANISM(S): Mus musculus 
2020-08-19 | E-MTAB-8035 | biostudies-arrayexpress
TranscriptomicsAssessing the impact of XAB2 on gene expression and pre-mRNA splicing in mouse HEPA cells
Xab2 knock down followed by RNA-sequencing of oligo-dT selected transcipts
ORGANISM(S): Mus musculus 
2020-08-19 | E-MTAB-8037 | biostudies-arrayexpress
GenomicsTranscriptome-wide identification of splicing defects upon XAB2 knockdown
Transcriptome-wide identification of splicing defects upon XAB2 knockdown
PRJNA533814 | ENA
TranscriptomicsTranscriptome-wide identification of splicing defects upon XAB2 knockdown
We performed RNA-seq to determine the impact of XAB2 depletion on global splicing. The results show that XAB2 depletion using two different siRNAs led to a wide range of splicing defects, with more than 50% events were intron retention.
ORGANISM(S): Homo sapiens 
2019-09-23 | GSE130087 | GEO
GenomicsThe impact of XAB2 on gene expression and pre-mRNA splicing
The impact of XAB2 on gene expression and pre-mRNA splicing
PRJEB32951 | ENA
TranscriptomicsXAB2 binds genome-wide on putative DNA elements (e.g. enhancers, promoters) that are known to regulate gene expression
XAB2 ChIP-Seq profile of mESCs treated with trans-retinoic acid (tRA), a pleiotropic factor known to activate transcription and regulate gene expression during cell differentiation and embryonic development and CHIP-Seq profile of the same cells untreated.
ORGANISM(S): Mus musculus 
2020-08-19 | E-MTAB-8033 | biostudies-arrayexpress
GenomicsAssessing the impact of XAB2 on gene expression and pre-mRNA splicing
Assessing the impact of XAB2 on gene expression and pre-mRNA splicing
PRJEB32953 | ENA
UnknownXAB2 dynamics during DNA damage-dependent transcription inhibition.
Not available
S-EPMC9436415 | biostudies-literature
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