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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
TranscriptomicsExpression data from RUNX1(41-214)-expressing and Runx1-knockout mice KSL cells
Mutations of RUNX1 are detected in patients with myelodysplastic syndrome (MDS). In particular, C-terminal truncation mutations lack a transcription regulatory domain and have increased DNA binding through the runt homology domain (RHD). The expression of the RHD, RUNX1(41-214), in mouse hematopoiet...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-40155 | biostudies-arrayexpress
UnknownDeficiency in Fpr2 results in reduced numbers of Lin-cKit+Sca1+ myeloid progenitor cells.
Not available
S-EPMC6120191 | biostudies-literature
UnknownAncient genomes from the Tang Dynasty capital reveal the genetic legacy of trans-Eurasian communication at the eastern end of Silk Road.
Not available
S-EPMC11577736 | biostudies-literature
UnknownYiqi Chutan Tang Reduces Gefitinib-Induced Drug Resistance in Non-Small-Cell Lung Cancer by Targeting Apoptosis and Autophagy.
Not available
S-EPMC7004076 | biostudies-literature
UnknownFoliar application of salicylic acid inhibits the cadmium uptake and accumulation in lettuce (Lactuca sativa L.).
Not available
S-EPMC10452881 | biostudies-literature
UnknownPTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.
Not available
S-EPMC6082900 | biostudies-literature
UnknownCoupled strategy based on regulator manipulation and medium optimization empowers the biosynthetic overproduction of lincomycin.
Not available
S-EPMC10840354 | biostudies-literature
MetabolomicsThe Formation of Phenol and Indole Flavor Substances in Stinky Tofu Brine Based on Metabolism of Aromatic Amino Acids

Understanding the formation mechanism of the flavor compounds in stinky tofu brine is crucial for controlling the flavor quality of Changsha stinky tofu. Dynamic changes in associated bacteria, enzymes, and differential metabolites in the metabolic pathway of aromatic amino acids in brine were in...

2026-03-20 | MTBLS2849 | MetaboLights
UnknownNetwork pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer.
Not available
S-EPMC7519149 | biostudies-literature
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