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TranscriptomicsGlobal DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we perfor...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-27895 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput sequencing of primordial germ cells from e6.5, e7.5, e8.5 embryos and e7.5 somatic neighbours and Blimp1-KO mice
Primordial germ cell mRNA profiles from cells microdissected from e6.5, e7.5 and e8.5 embryos, e7.5 somatic neighbours and Blimp1-KO mice were generated by single cell library construction and sequencing in duplicate using Applied Biosystems SOLiD sequencer. Single cell library construction is descr...
ORGANISM(S): Mus musculus 
2013-07-01 | E-MTAB-1178 | biostudies-arrayexpress
ProteomicsIdentification of novel blood-borne soluble binding partners of factor H-related proteins
The deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases. However, the array of blood-borne binding partners with which they interact remains unclear. Here, we identify novel blood-borne bindin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD072296 | Pride
Fhr Affinity proteomics Blood 
TranscriptomicsThe Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-04 | E-GEOD-38601 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of mouse embryonic day 3.5 blastocyst inner cell mass cells
Inner cell mass (ICM) cells of two independent E3.5 blastocysts were profiled by transcriptome sequencing to assess the expression of extracellular matrix components.
ORGANISM(S): Mus musculus 
2014-05-15 | E-MTAB-2555 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of single cells from the Arabidopsis root
The definition of cell identity is a central problem in biology. Single-cell RNA-seq provides a wealth of information regarding the developmental state of individual cells. However, better methods are needed to map the identity of single cells, especially during identity transitions. We have develop...
ORGANISM(S): Arabidopsis thaliana 
2015-03-12 | E-MTAB-4125 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of marmoset embryonic development
Transcriptional profiling of common marmoset embryo stages spanning E5.0 to E7.0 was performed by RNA-seq.
ORGANISM(S): Callithrix jacchus 
2015-11-05 | E-MTAB-2959 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of mouse embryonic development
Transcriptional profiling of mouse embryos spanning the 8-cell morula stage to E5.5 postimplantation epiblast was performed using lineage-specific RNA-seq.
ORGANISM(S): Mus musculus 
2015-11-09 | E-MTAB-2958 | biostudies-arrayexpress
TranscriptomicsTranscriptome characterization of venous endothelium during the formation of neointimal hyperplasia and stenosis in a rat arteriovenous fistula model for kidney dialysis
In patients with severe kidney disease AVF are surgically placed in order to create good access for hemodialysis. In these dialysis patients the failure rates of AVF can be as high as 24% within 6 months after surgery, causing ineffective dialysis and necessitating additional clinical interventions....
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-46126 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression of wild-type and Li2 mutant fibers during initiation or early elongation
Gene expression profiling of wild-type and Li2 mutants were investigated with Affymetrix cotton Genome Array focused primarily on time-points related to fiber elongation, more specifically, 8 and 12 days post anthesis (DPA). These time points typically represent peak rates of elongation and the begi...
ORGANISM(S): Gossypium hirsutum 
2012-07-05 | E-MEXP-3306 | biostudies-arrayexpress
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