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TranscriptomicsProfiling downregulation of the mevalonate pathway in Staphylococcus aureus
Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophospha...
ORGANISM(S): Staphylococcus aureus RN4220 
2010-05-05 | E-GEOD-13424 | biostudies-arrayexpress
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
GenomicsSingle Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [RRBS]
Differentiated cell can be reprogrammed into totipotent embryo through somatic cell nuclear transfer (SCNT). However, this process is highly inefficient and most cloned embryos arrest at certain developmental stages. Through single cell sequencing combined with embryo biopsy, here we generate a glob...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-70607 | biostudies-arrayexpress
UnknownXIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis
Not available
S-SCDT-10_1038-S44319-024-00092-Y | biostudies-other
ProteomicsOxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy
Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple stressors. However, the mechanisms underlying autophagy initiation upon hypoxia remains unclear. This study identifi...
ORGANISM(S): Homo Sapiens 
2022-01-25 | PXD031209 |
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