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TranscriptomicsIdentification of Neuronal RNA Targets of TDP-43-Containing Ribonucleoprotein Complexes
We identify the RNA targets of TAR DNA-binding protein 43 (TDP-43) from cortical neurons by RNA immunoprecipitation followed by deep sequencing (RIP-seq). We identify 4352 highly enriched RNA targets of TDP-43. We determined that the canonical TDP-43 binding site (TG)n was 55.1-fold enriched in our ...
ORGANISM(S): Rattus norvegicus 
2010-11-04 | E-GEOD-25032 | biostudies-arrayexpress
ProteomicsMapping of TDP-43 ubiquitination and acetylation sites
TAR DNA binding protein of 43 kDa (TDP-43) forms aggregates in neurodegenerative diseases, particularly certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Pathological modifications of TDP-43 include proteolytic fragmentation, phosphorylation, and ubiquitinylation. In this s...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD030170 | Pride
Acetylation Ubiquitination Tdp-43 
TranscriptomicsAltered Distributions of SMN-containing GEMs and Mitochondria in Motor Neurons of TDP-43 transgenic Mice
TDP-43, a DNA/RNA binding protein involved in RNA transcription and splicing has been associated with the pathophysiology of neurodegenerative diseases, including ALS. However, the function of TDP-43 in motor neurons remains undefined. Here, we employ both gain- and loss-of-function approaches to de...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22351 | biostudies-arrayexpress
TranscriptomicsTDP-43 regulates cancer-associated microRNAs
MicroRNAs (miRNAs) play important roles in a wide range of cellular processes. Aberrant regulation of miRNA genes contributes to human diseases, including cancer. The TAR DNA binding protein 43 (TDP-43), a DNA/RNA binding protein associated with neurodegeneration, is involved in miRNA biogenesis. He...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85065 | biostudies-arrayexpress
TranscriptomicsDecrease of Parkin and CD36 expression and body weight correlate with an increase of non-esterified fatty acids in a mouse model for TDP-43 pathology
TDP-43-coding mutations are found among ALS patients. In oder to express human mutant TDP-43 protein in the mouse under the control of the endogenous Tardp promoter, we have generate a mouse line wit 300% elevated TDP-43 level. Total RNA obtained from 4-6 male mutant mice was compared to 4-6 wild ty...
ORGANISM(S): Mus musculus 
2014-05-21 | E-GEOD-39585 | biostudies-arrayexpress
GenomicsTDP-43 is a genome-wide DNA-binding protein and regulator of snRNA expression
TDP-43 is a genome-wide DNA-binding protein and regulator of snRNA expression
PRJNA483467 | ENA
ProteomicsNative State Stabilization is an Effective Strategy to Inhibit TDP-43 Oligomerization and Fibrillogenesis
Transactive response DNA-binding protein 43 kDa (TDP-43) is a partially disordered nuclear protein that plays essential roles in RNA metabolism to maintain cellular homeostasis. In individuals with neurodegenerative diseases (NDDs), including Amyotrophic lateral Sclerosis (ALS), Alzheimer’s disease,...
ORGANISM(S): Homo sapiens (Human) Bacteria 
2026-06-24 | PXD041160 | Pride
Hdx-ms Aggregation Neuronal toxicity Oligonucleotides Tar dna binding protein (tdp-43) 
TranscriptomicsComprehensive Transcriptomic Analysis of BV2 Microglia Following TDP-43 Knockdown Versus Non-Silencing Control
In this study, we investigate how knockdown of the RNA-binding protein TDP-43 alters the transcriptional program of BV2 microglial cells. Aberrant TDP-43 function is a hallmark of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and while most...
ORGANISM(S): Mus musculus 
2025-07-21 | E-MTAB-15184 | biostudies-arrayexpress
ProteomicsTDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord
Neuronal and glial cytoplasmic inclusions positive for TAR DNA-binding protein 43 (TDP-43) are the defining pathological hallmark of 97% of amyotrophic lateral sclerosis (ALS) and 50% of frontotemporal dementia (FTD). The ALS-FTD clinicopathological spectrum variably involves cortical and spinal ant...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD067060 | Pride
Proteomics Tissue Brain Tdp-43 Amyotrophic lateral sclerosis Spinal cord 
GenomicsTDP-43 is a genome-wide DNA-binding protein and regulator of snRNA expression
TAR DNA-binding protein 43 (TDP-43) is the major protein component of neuronal inclusions characterizing the adult-onset neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-TDP). Whereas TDP-43 was originally identi...
ORGANISM(S): Homo sapiens 
2023-12-21 | GSE117873 | GEO
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