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GenomicsJarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
We report on mechanism of interaction between PRC2 complex and Jarid2 and their role in pluripotent cells Examination of PRC2 genomic localization by analysis of Jarid2, Ezh2, Suz12 and Jarid1a occupancy
ORGANISM(S): Mus musculus 
2009-12-24 | E-GEOD-18776 | biostudies-arrayexpress
TranscriptomicsAnalysis of HSF2 target genes using a global promoter ChIP-chip strategy on mouse wild-type testis
Mapping of in vivo targets for HSF2 by using mammalian tissue material in a global ChIP-chip promoter screen. Chromatin was isolated from three wild-type (WT) mouse testes, crosslinked and sonicated into fragments of 100-500 bp, and the quality of the DNA was controlled before the immunoprecipitatio...
ORGANISM(S): Mus musculus 
2008-08-05 | E-GEOD-9289 | biostudies-arrayexpress
GenomicsClinical and biological implications of target occupancy in chronic lymphocytic leukemia treated with acalabrutinib
Clinical and biological implications of target occupancy in chronic lymphocytic leukemia treated with acalabrutinib
PRJNA562903 | ENA
UnknownAn Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors.
Not available
S-EPMC6156402 | biostudies-literature
TranscriptomicsGenome-Wide Yan Chromatin Occupancy in Drosophila Embryos
The ETS transcriptional repressor Yan functions as part of a developmental switch that in response to receptor tyrosine kinase signaling, transitions from a high-Yan to a low-Yan state to direct specification of a variety of cell fates. To date very few direct target genes have been identified, nor ...
ORGANISM(S): Drosophila melanogaster 
2013-03-01 | E-GEOD-34038 | biostudies-arrayexpress
UnknownXPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose.
Not available
S-EPMC5746399 | biostudies-literature
TranscriptomicsCell cycle dependent nucleosome occupancy at cohesin binding sites in yeast chromosomes
Nucleosome organization determines local chromatin structure and changes in nucleosome occupancy during the cell cycle are correlated with nuclear functions. We used oligonucleotide tiling arrays to analyze the cell cycle dependence of nucleosome occupancy at cohesin binding sites in yeast chromosom...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-26 | E-GEOD-8130 | biostudies-arrayexpress
ProteomicsPEPseq Quantifies Transcriptome-Wide Changes in Protein Occupancy and Reveals Selective Translational Repression After Translational Stress
Post-transcriptional gene regulation is accomplished by the interplay of the transcriptome with RNA-binding proteins, which occurs in a dynamic manner in response to altered cellular conditions. Recording the combined occupancy of all proteins binding to the transcriptome offers the opportunity to i...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042395 | Pride
Nascent proteome enrichment Protein-rna crosslinking Aha Protein occupancy on rna Arsenite washout Recovery from translational arrest Silac 
GenomicsNOTCH1/RBPJ complexes drive target gene expression through dynamic interactions with super-enhancers
The main oncogenic driver in T-lymphoblastic leukemia (T-LL) is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase (GSI) inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1 binding sites are insensitive to GSI...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51800 | biostudies-arrayexpress
TranscriptomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [expression]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-46645 | biostudies-arrayexpress
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