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GenomicsDevelopment of potent and selective KDM5 covalent inhibitors
Development of potent and selective KDM5 covalent inhibitors
PRJNA486160 | ENA
UnknownAssessing Lysine and Cysteine Reactivities for Designing Targeted Covalent Kinase Inhibitors.
Not available
S-EPMC6935298 | biostudies-literature
UnknownDiscovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
Not available
S-EPMC7136196 | biostudies-literature
UnknownTargeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX.
Not available
S-EPMC11651660 | biostudies-literature
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054057 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
UnknownCreating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy.
Not available
S-EPMC9827112 | biostudies-literature
UnknownSelective and Effective: Current Progress in Computational Structure-Based Drug Discovery of Targeted Covalent Inhibitors.
Not available
S-EPMC7669701 | biostudies-literature
GenomicsDevelopment of potent and selective KDM5 covalent inhibitors
Histone lysine demethylase (KDMs) are involved in the dynamic regulation of gene expression by reversible regulation of the methylation levels on lysine residues in histone tails. Among the KDMs, the jumonji (JmjC)-domain-containing KDMs (KDM2-7) are Fe(II), 2- OG (α-ketoglutarate) and molecular oxy...
ORGANISM(S): Homo sapiens 
2018-12-10 | GSE118589 | GEO
UnknownExploring Extended Warheads toward Developing Cysteine-Targeted Covalent Kinase Inhibitors.
Not available
S-EPMC11684028 | biostudies-literature
UnknownQuantum Chemical Characterization of Rotamerism in Thio-Michael Additions for Targeted Covalent Inhibitors.
Not available
S-EPMC11480980 | biostudies-literature
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