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ProteomicsAnalysis of protein expression change upon RBMS1 knockdown
To assess how dpeletion of RBMS1 affects the proteome, SW480 colon adenocarcinoma cells expressing control or RBMS1 shRNAs were compared by Tandem Mass Tagging (TMT) protoemics.
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD019478 | Pride
Rbms1  tmt  rna binding protein 
ProteomicsProtoemics on HIPPOCAMPi FROM PARTIAL-BODY IRRADIATED MICE
Background: The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. Aim: The goal of this study is to test...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024975 | Pride
2 weeks Shotgun proteomics 6 month Low radiation Hippocampus 
ProteomicsTargeted proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, using label-free PRM approach which is allowing ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006556 | Pride
Targeted protoemics Quantitative analysis Label-free prm Bv2 activation 
ProteomicsA system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells
Molecular heterogeneity of tumors, epigenetic changes and a diverse range of molecular mechanisms are main contributors to drug resistance, which represents one of the great challenges in cancer treatment. A deeper understanding of the molecular biology of cancer has resulted in better targeted ther...
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD007740 | Pride
Ptpn11 Proteomics Colorectal cancer Multi-omics Drug resistance Braf(v600e) Phosphoproteomics Transcriptomics Egfr 
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