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ProteomicsA large-scale proteomic identification of targets of cellular miR-197 downregulated by enterovirus A71
MicroRNAs are noncoding RNA species comprising 18–23 nucleotides that regulate host-virus interaction networks. Here, we showed that enterovirus A71 infection in human rhabdomyosarcoma (RD) involved miR-197 expression. miR-197 can regulate virus replication in the context of viral RNA synthesis via ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD010585 | Pride
Viral replication Targetscan Microrna Silac Mir-197 Enterovirus a71 
TranscriptomicsAnalysis of mir-17~92 targets in motor neurons
To identify mir-17~92 targets in MNs, a set of target candidate genes from the intersection of upregulated genes found only in the mir-17~92 KO MNs that were predicted to be direct targets of mir-17~92 by TargetScan.
ORGANISM(S): Mus musculus 
2015-04-14 | GSE67795 | GEO
TranscriptomicsTranscriptomic study of melanoma cell line A375 with miR-205 overexpression against controls
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma. We evaluated whole-genome mRNA expression profiling associated with different miR-205 expression levels in melanoma cells. Differential expression analysis, target p...
ORGANISM(S): Homo sapiens 
2020-03-19 | E-MTAB-8202 | biostudies-arrayexpress
GenomicsmicroRNA array analysis for seaching IGBP1-targeting microRNA in lung adenocarcinoma
Immunoglobulin (CD79a) binding protein 1 (IGBP1) is universally overexpressed in lung adenocarcinoma and exerts an anti-apoptotic effect by binding to PP2Ac. However, the molecular mechanism of IGBP1 overexpression is still unclear. In the present study, we used a microRNA (miRNA) array and TargetSc...
ORGANISM(S): synthetic construct Homo sapiens 
2016-11-11 | GSE89750 | GEO
TranscriptomicsUnderexpression of miR-224 in methotrexate resistant human colon cancer cells
A summary of the work associated to these microarrays is the following: MicroRNAs (miRNAs) are small non-coding RNAs involved in RNA silencing that play a role in many biological processes. They are involved in the development of many diseases, including cancer. Extensive experimental data show tha...
ORGANISM(S): Homo sapiens 
2013-05-29 | E-GEOD-28547 | biostudies-arrayexpress
TranscriptomicsMiR-26a targets EphA2 to resist intracellular Listeria monocytogenes in macrophages
We performed transcriptome analyses of miR-26a-overexpressing RAW264.7 cells (RAW264.7.miR-26a.OE) and NC-plasmid-transfected RAW264.7 cells (RAW264.7.NC), using RNA-seq . We identified 121 genes that were downregulated in RAW264.7.miR-26a.OE cells compared with RAW264.7.NC cells. Among the downregu...
ORGANISM(S): Mus musculus 
2022-06-01 | GSE149842 | GEO
TranscriptomicsThe investigation of target gene of antisense oligonucleotides (ASOs) against microRNA-21 in colorectal carcinoma cells in vivo
To further elucidate the potential molecular mechanism through which down-regulated the expression level of miR-21 affected the growth of colorectal carcinoma cells, we used TargetScan and MIRDB software to screen out 16 genes, and 5 genes were up-regulated, putative target genes of miR-21 including...
ORGANISM(S): Homo sapiens 
2018-01-25 | GSE109592 | GEO
TranscriptomicsThe role of microRNAs in hepatic thyroid hormone signalling
MicroRNAs (miRNAs) are extensively in diverse biological processes. However, very little is known about the role of miRNAs in mediating thyroid hormones (TH) action. Maintenance of appropriate TH levels is known to be critically important for development, differentiation and maintenance of metabolic...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-21277 | biostudies-arrayexpress
GenomicsWhole genome miRNA expression profiling using HeLa cells in response to Heat shock stress.
Exiqon miRNA array contains LNA-modified oligos which minimizes the Tm-range within which probe hybridizes with the transcript in query, thus minimizing the mis-match. Taking advantage of this, we used the miRCURY LNA array to investigate genome wide signatures for miRNA expression in response to he...
ORGANISM(S): Murid gammaherpesvirus 4 Betapolyomavirus hominis Mus musculus Rattus norvegicus Murid betaherpesvirus 1 JC polyomavirus Human immunodeficiency virus 1 Human gammaherpesvirus 8 Homo sapiens Human alphaherpesvirus 1 Human betaherpesvirus 5 human gammaherpesvirus 4 Betapolyomavirus macacae 
2015-01-01 | GSE60472 | GEO
GenomicsLncRNA-miRNA-mRNA network interactions with clinicopathological outcomes in gastric cancer patients
To investigate lncRNA-miRNA-mRNA network interactions with clinicopathological outcomes in gastric cancer, microarray analysis was obtained by microRNA profiling from the patient samples. The potential target genes were then predicted by miRmap, targetscan, and miRWalk2.0. The candidate lncRNAs were...
ORGANISM(S): Homo sapiens 
2022-07-02 | GSE207154 | GEO
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