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GenomicsMot1 redistributes TBP from TATA-containing to TATA-less promoters
The Swi2/Snf2-family ATPase Mot1 displaces TBP from DNA in vitro, but the global relationship between Mot1 and TBP in vivo has been unclear. We therefore mapped the distribution of Mot1 and TBP on native chromatin at base-pair resolution. Mot1 and TBP binding sites coincide throughout the genome, ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-21 | E-GEOD-44200 | biostudies-arrayexpress
ProteomicsTAF4 immunoprecipitation from mouse embryonic stem cells
TAF4 directed immunoprecipitation of the the Pre-initiation complex from mouse embryonic stem cells with or without depletion of TATA-box binding protein (TBP).
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-05-27 | MSV000089562 | MassIVE
TranscriptomicsTranscription profiling of mouse cerebellum cells containing expanded or normal CAG trinucleotide repeats in the coding region for TATA-binding protein (TBP)
Transcription profiles were obtained for 2-month old mice containing an expanded or normal CAG trinucleotide repeat in the coding region for TATA-binding protein (TBP). Three different genotypes were used : TBP-13Q (normal), TBP-71Q (71 repeats), and TBP-105Q (105 repeats). Two lines of TBP-71Q (li...
ORGANISM(S): Mus musculus 
2007-11-09 | E-MEXP-1313 | biostudies-arrayexpress
TranscriptomicsTBP ChIP-chip on Jurkat cells
During mitosis, TATA-binding protein(TBP), which remains bound to DNA during mitosis, recruits PP2A and also interacts with a subunit of the condensin complex to allow efficient dephosphorylation and inactivation of condensin near these promoters to inhibit their compaction. These result suggest tha...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-12256 | biostudies-arrayexpress
GenomicsInteraction between TBP and condensing drives the organization and faithful segregation of mitotic chromosomes
Genome/chromosome organization is highly ordered and controls nuclear events. Here, we show that the TATA box-binding protein (TBP) interacts with the Cnd2 kleisin subunit of condensin to mediate interphase and mitotic chromosome organization in fission yeast. TBP recruits condensin onto RNA polymer...
ORGANISM(S): Schizosaccharomyces pombe 
2015-08-12 | E-GEOD-60273 | biostudies-arrayexpress
GenomicsInterconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.
The conserved core domain of the TATA binding protein (TBP) interacts with multiple partners forming the complexes required for transcription by RNA Polymerases I, II and III. We use genetically modified mouse embryonic fibroblasts to show that many TBP core domain mutants complement loss of endogen...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-27908 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cerebellum cells from wild type mice or mice overexpressing TATA-binding protein (TBP) or a mutant version of TBP
Transcription profiles were obtained for 2-month old mice. Three lines (WT, TBP-13Q12, and TBP105Q) were used in these experiments.

Wild-type and 13Q mice are normal. The 13Q mice overexpress the normal protein on the RNA but not protein level and do not show a phenotype. The 105Q mice exp...
ORGANISM(S): Mus musculus 
2007-11-09 | E-MEXP-1314 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Xenopus laevis early gastrulation embryos injected with antisense oligonucleotides against TBP, TLF or TBP2
Xenopus laevis embryos were injected with antisense oligonucleotides against TBP, TLF or TBP2. Embryos were allowed to develop up to stage 7 (non-injected control embryos) or stage 10.5 (early gastrula, control and antisense injected embryos) and subsequently collected for RNA and protein isolation...
ORGANISM(S): Xenopus laevis 
2007-08-29 | E-MEXP-1009 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of TBP, NC2alpha, NC2beta, Mot1p, Spt20p, Taf1p and Rpb3p in yeast grown at 4% and shifted to 0.1% glucose
ChIP-chip of TBP, NC2alpha, NC2beta, Mot1p, Spt20p, Taf1p and Rpb3p of cells grown at 4% and shifted to 0.1% glucose.
ORGANISM(S): Saccharomyces cerevisiae 
2008-09-01 | E-MTAB-21 | biostudies-arrayexpress
TranscriptomicsChIP-chip from H9 hESCs for RNA Polymerase II, TBP, TAF3, TAF5, TAF7, and TAF11
The general transcription factor TFIID is composed of the TATA-box-binding protein (TBP) and approximately 14 TBP-associated factors (TAFs). Here we find, unexpectedly, that undifferentiated human embryonic stem cells (hESCs) contain only six TAFs (TAFs 2, 3, 5, 6, 7 and 11), whereas following diffe...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-39312 | biostudies-arrayexpress
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