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UnknownPathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems.
Not available
S-EPMC6984766 | biostudies-literature
ProteomicsAxonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticity
Tau pathology is a major hallmark of Alzheimer’s disease (AD) and related diseases, called tauopathies. While Tau is normally enriched in axons, somatodendritic missorting of the microtubule-associated protein is a key event in early disease development. Tau missorting promotes synaptic loss and neu...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD053880 | Pride
Proline-rich region 2 Alzheimer’s disease Tau missorting Tau isoforms Synaptic tau Cdc42 Rab11 
UnknownActivated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity.
Not available
S-EPMC6584807 | biostudies-literature
UnknownAxodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
Not available
S-EPMC5519369 | biostudies-literature
UnknownEndo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting.
Not available
S-EPMC8324842 | biostudies-literature
UnknownTau protein is essential for stress-induced brain pathology.
Not available
S-EPMC4932951 | biostudies-literature
UnknownA mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons.
Not available
S-EPMC8816743 | biostudies-literature
ProteomicsIgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity
Anti-IgLON5 disease is an autoimmunity/neurodegeneration overlap disorder, in which autoantibodies (AABs) against the neuronal cell surface protein IgLON5 lead to profound brain dysfunction. Whether neuronal Tau protein pathology and neurodegeneration found in the patient’s brains are directly relat...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-21 | PXD066225 | Pride
UnknownThe potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
Not available
S-EPMC6670355 | biostudies-literature
UnknownMissorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.
Not available
S-EPMC6672561 | biostudies-literature
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