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ProteomicsA pilot study for deciphering post-translational modifications and proteoforms of tau protein by capillary electrophoresis-mass spectrometry
Abnormal accumulation of tau proteins is one pathological hallmark of Alzheimer’s disease (AD). Many tau protein post-translational modifications (PTMs) are associated with the development of AD, such as phosphorylation, acetylation, and methylation. Therefore, a complete picture of PTM landscape of...
ORGANISM(S): Escherichia coli 
2024-10-15 | PXD053367 | Pride
Alzheimer’s disease Capillary electrophoresis-mass spectrometry Post-translational modification Tau protein Phosphorylation Proteoform 
ProteomicsThe Proteoform Landscape of Tau from the Human Brain
Tau is a microtubule-associated protein (MAP) and critical for maintaining the cytoskeleton of neurons. Tau and its post-translational modifications (PTMs) have been studied for decades, yet the exact composition of intact tau and its truncation products present in the human brain have evaded study ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD061278 | Pride
Tau proteoforms Alzheimer's disease Immunoprecipitation Top-down tandem mass spectrometry Individual ion mass spectrometry 
UnknownPilot Study for Deciphering Post-Translational Modifications and Proteoforms of Tau Protein by Capillary Electrophoresis-Mass Spectrometry.
Not available
S-EPMC11536466 | biostudies-literature
ProteomicsComprehensive Mapping of the Tau Antibody Landscape as a Resource for Western Blotting and ImmunohistochemistryComprehensive Mapping of the Tau Antibody Landscape as a Resource for Western Blotting and Immunohistochemistry
Background: The microtubule-associated protein Tau has attracted a diverse and ever-increasing research interest, with the protein being mentioned in the title/abstract of nearly 34,000 PubMed-indexed publications to-date. To facilitate studies into Tau biology and its role in neurodegeneration, a m...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041199 | Pride
Antibody validation Tau Mapt 
UnknownImmunoassay detection of multiphosphorylated tau proteoforms as cerebrospinal fluid and plasma Alzheimer's disease biomarkers.
Not available
S-EPMC11696609 | biostudies-literature
ProteomicsTau Profiling of Brain Extracellular Vesicles Reveals PHF6 Peptide as Core for Pathological Tau Seeding in Alzheimer's Disease
EVs are bilipid spheres known for their role in cellular communication through transport of proteins, lipids, RNA and more. In the brain, EVs are directly released in the interstitial fluid surrounding neural cells and hence entitled brain-derived EVs (BD-EVs). Human BD-EVs of AD patients contain se...
ORGANISM(S): Homo Sapiens 
PXD067593 | panorama
UnknownSpectraSage unveils specific proteolytic patterns of 20S on mono-ubiquitylated Tau proteoforms involved in neurodegeneration.
Not available
S-EPMC12379967 | biostudies-literature
UnknownIdentification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry.
Not available
S-EPMC11102361 | biostudies-literature
ProteomicsMolecular features of human pathological Tau distinguish tauopathy-associated dementias (primary cohort FLEXITau)
In Alzheimer’s disease (AD), pathological Tau protein shows a progressive accumulation of post-translational modifications (PTMs), reflecting disease severity, progression, and prion-like activity. While many neurodegenerative diseases with dementia display Tau aggregates, the pathological proteofor...
ORGANISM(S): Homo sapiens (Human) 
2026-02-19 | PXD069437 | Pride
Neurodegeneration  post-translational modification  proteolytic cleavage  clinical diagnosis  classification  human tau  srm  proteopathy  protein aggregation 
ProteomicsMolecular features of human pathological Tau distinguish tauopathy-associated dementias (secondary cohort FLEXITau)
In Alzheimer’s disease (AD), pathological Tau protein shows a progressive accumulation of post-translational modifications (PTMs), reflecting disease severity, progression, and prion-like activity. While many neurodegenerative diseases with dementia display Tau aggregates, the pathological proteofor...
ORGANISM(S): Homo sapiens (Human) 
2026-02-19 | PXD069217 | Pride
Neurodegeneration  post-translational modification  proteolytic cleavage  clinical diagnosis  classification  human tau  srm  proteopathy  protein aggregation 
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