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Tauroursodeoxycholic acid (TUDCA), an endogenous neuroprotective bile acid and a metabolic regulator, stimulates NSC proliferation and enhances adult NSC pool in vitro and in vivo. In this study, we dissected the mechanism triggered by this proliferation-inducing molecule, namely in mediating metabo...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD017979 | Pride
Tauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation
Transcriptome profile of S. cerevisiae treated with tauroursodeoxycholic acid (TUDCA)

Introduction: Guanxinning tablet (GXNT), a traditional Chinese medicine preparation, has been found to improve lipid metabolism in patients with cardiovascular disease. However, the underlying mechanisms are still poorly understood. This study aims to determine whether the gut micr...

2026-03-20 | MTBLS14095 | MetaboLights
COL4A3/A4/A5 mutations have been identified as critical causes of Alport syndrome and other genetic chronic kidney diseases. However, the underlying pathogenesis remains unclear, and specific treatments are lacking. Here, we constructed a transgenic Alport syndrome mouse model by generating a mutati...
ORGANISM(S): Mus musculus 
2024-08-28 | GSE261588 | GEO
Not available
ORGANISM(S): Gallus gallus 
Not available
ORGANISM(S): Mus musculus 
Tauroursodeoxycholic acid prevents acute graft-versus-host disease in mice by regulating intestinal apoptosis and inflammation

Hepatic fibrosis decreased feces bile acid level. Hepatic fibrosis increased serum bile acid. This result showed that hepatic fibrosis inhibited the excretion of bile acid in clinical patients. This result provided phenotype for hepatic fibrosis patients. Bile acid was important indexes for liver...

2023-03-17 | MTBLS6742 | MetaboLights

Hepatic fibrosis decreased feces bile acid level. Hepatic fibrosis increased serum bile acid. This result showed that hepatic fibrosis inhibited the excretion of bile acid in clinical patients. This result provided phenotype for hepatic fibrosis patients. Bile acid was important indexes for liver...

2023-03-17 | MTBLS6732 | MetaboLights
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