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ProteomicsCardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism
The growing field of cardio-oncology addresses the side effects of cancer treatment on the cardiovascular system. Here, we explored the cardiotoxicity of the antiangiogenic therapy, sunitinib, in the mouse heart from a diagnostic and therapeutic perspective. We showed that sunitinib induces an anaer...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-14 | PXD006888 | Pride
Cardiotoxicity Sunitinib Positron emission tomography Endothelin Cardio-oncology Echocardiography Macitentan 
ProteomicsAcute stress induces long-term metabolic, functional and structural remodeling of the heart
Takotsubo syndrome is a stress-induced cardiomyopathy with symptoms comparable to those of acute coronary syndrome but without coronary obstruction. Initially considered spontaneously reversible, the reversibility of takotsubo was challenged by epidemiological studies showing high morbi-mortality in...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-28 | PXD032667 | Pride
Tims tof pro Mouse heart takotsubo model Label-free quantification Stress-induced cardiomyopathy 
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