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TranscriptomicsCommensal microbiota contributes to chronic endocarditis and arrhythmia in TAX1BP1 deficient mice.
Tax1-binding protein 1 (Tax1bp1) negatively regulates NF-κB by editing the ubiquitylation of target molecules with its catalytic partner A20. Genetically engineered TAX1BP1-deficient (KO) mouse develops age-dependent inflammatory constitution in multiple organs including heart, liver, skin and succu...
ORGANISM(S): Mus musculus 
2014-02-01 | E-GEOD-43932 | biostudies-arrayexpress
Proteomicsp97/VCP is required for piecemeal autophagy of aggresomes
Metazoan cells adapt to the exhaustion of protein quality control (PQC) systems by sequestering aggregation-prone proteins in large, pericentriolar structures termed aggresomes. Defects in both, aggresome formation and clearance affect proteostasis and have been linked to neurodegenerative diseases,...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD053581 | Pride
Aggrephagy Proximity proteomics Turboid Protein quality control Tax1bp1 P97/vcp Piecemeal autophagy 
GenomicsTax1bp1 promotes inflammatory signaling and necrosis during Mycobacterium tuberculosis infection of alveolar macrophages
Tax1bp1 promotes inflammatory signaling and necrosis during Mycobacterium tuberculosis infection of alveolar macrophages
PRJNA1178315 | ENA
GenomicsTAX1BP1 deficiency impair initiation of autophagic flow in HK-2 cells through downregulate AMPK-ULK1 pathway
TAX1BP1 deficiency impair initiation of autophagic flow in HK-2 cells through downregulate AMPK-ULK1 pathway
PRJNA1083895 | ENA
UnknownTax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
Not available
S-EPMC7530720 | biostudies-literature
TranscriptomicsTax1bp1 promotes inflammatory signaling and necrosis during Mycobacterium tuberculosis infection of alveolar macrophages
Crosstalk between autophagy, host cell death, and inflammatory host responses to bacterial pathogens enables effective innate immune responses that limit bacterial growth while reducing coincidental host damage. Mycobacterium tuberculosis thwarts innate immune defense mechanisms in alveolar macropha...
ORGANISM(S): Mus musculus 
2025-02-12 | GSE280399 | GEO
TranscriptomicsTAX1BP1 deficiency impair initiation of autophagic flow in HK-2 cells through downregulate AMPK-ULK1 pathway
Selective autophagy receptor can combine with substrate in cells to degrade them and maintain cellular homeostasis. TAX1BP1, a kind of selective autophagy receptor, has N-terminal SKIP carboxyl homology (SKICH) domain (LC3-Interacting Region) and a C-terminal ubiquitin binding domain (UBD).TAX1BP1 c...
ORGANISM(S): Homo sapiens 
2024-05-01 | GSE260876 | GEO
UnknownRegulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.
Not available
S-EPMC4981851 | biostudies-literature
UnknownTax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability.
Not available
S-EPMC2643713 | biostudies-literature
Genomics
RNA-Seq of monocytes/macrophages with TAX1BP1 knockdown
PRJNA895682 | ENA
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