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TranscriptomicsComparative Genomic Hybridization of E. coli and Shigella species to determine the relatedness of isolates from Neobladders
Using comparative genomic hybridization we examined the genome content of 30 isolates of E. coli and Shigella to determine the relative location of E. coli isolates from the human neobladder Isolates were included in the study that represent the prototype strains of multiple pathovars. No replicate...
ORGANISM(S): Shigella sonnei 
2011-07-24 | E-GEOD-27326 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate cancer cells, normal epithelial prostatic cells and stroma cells from patients in placebo, selenium, vitamin E or selenium and vitamin E treatment groups
85 radical prostatectomy specimens (where 16 samples are in Placebo group (PL), 15 are in Selenium group (SE), 25 are in Vitamin E group (VE) and 27 are in Vitamin E & Selenium group (VS.Treatment groups: l-selenomethionine, 400 ug + placebo (vitamin E); vitamin E, 400 IU + placebo (l-selenomethion...
ORGANISM(S): Homo sapiens 
2008-07-01 | E-MEXP-1327 | biostudies-arrayexpress
UnknownIdentification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.
Not available
S-EPMC24228 | biostudies-literature
UnknownMulticomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Not available
S-EPMC4638191 | biostudies-literature
MetabolomicsThe genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

Cyclic peptides are reported to have antibacterial, antifungal and other bioactivities. Orbitides are a class of cyclic peptide that are small, head-to-tail cyclized, composed of proteinogenic amino acids, and lack disulfide bonds; they are also known in several genera of the plant family Rutacea...

2020-10-14 | MTBLS1963 | MetaboLights
ProteomicsDe novo heterozygous variants in POLR2A cause a neurodevelopmental syndrome with infantile-onset hypotonia
  ABSTRACT POLR2A encodes RPB1, the largest subunit of the RNA polymerase II (pol II) complex, which is responsible for transcription of all ~21,000 protein-encoding genes. Here we describe the first fifteen patients harboring de novo heterozygous variants in POLR2A. The majority presents with profo...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD011355 | Pride
Rpb1 De novo heterozygous variants Polr2a Rna polymerase ii 
UnknownFunctional and mutational analysis of conjugative transfer region 2 (Tra2) from the IncHI1 plasmid R27.
Not available
S-EPMC145343 | biostudies-literature
TranscriptomicsTh single cell RNA-Seq
Th2 cells regulate helminth infections, allergic disorders, tumor immunity and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2-signaling molecules. While steroids are known to be immunoregulators, de novo steroid production from immune cells has not been previo...
ORGANISM(S): Mus musculus 
2014-04-25 | E-MTAB-2512 | biostudies-arrayexpress
UnknownThe Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study (InterGEN): Design and Methods for Recruitment and Psychological Measures.
Not available
S-EPMC4930011 | biostudies-literature
UnknownDiscovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Not available
S-EPMC10861881 | biostudies-literature
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