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GenomicsChIP-seq analysis of Rpb1 from 12hr conjugating Oxytricha trifallax cells
To study the biogenesis of long non-coding RNAs transcribed during genome rearrangements in Oxytricha development, genome-wide localization pattern of Rpb1 (RNA Pol-II largest subunit) was studied from Oxytricha cells undergoing conjugation. Chromatin from 12hr conjugating O.trifallax cells was subj...
ORGANISM(S): Oxytricha trifallax 
2014-03-08 | E-GEOD-55703 | biostudies-arrayexpress
TranscriptomicsExpression profiling of rpb1-12XWTCTD and rpb1-12XS2ACTD fission yeast strains.
In fission yeast, the nuclear-localized Lsk1p-Lsc1p-Lsg1p cyclin dependent kinase complex is required for the reliable execution of cytokinesis and is also required for Ser-2 phosphorylation RNA pol II carboxy terminal domain. To address whether alterations in CTD phosphorylation might selectively a...
ORGANISM(S): Schizosaccharomyces pombe 
2011-08-31 | E-GEOD-31369 | biostudies-arrayexpress
ProteomicsAOH1996, a small molecule ligand of PCNA, modulates PCNA interaction with RPB1
Targeting transcription replication conflicts, a major source of endogenous DNA double stranded breaks and genomic instability, could have important therapeutic implications. When transcription and DNA replication machineries encounter each other on chromosomes, one way to resolve the conflict is te...
ORGANISM(S): Homo sapiens (Human) 
2023-08-03 | PXD027782 | Pride
Apim motif Pcna Rpb1 Aoh1996 And transcription-replication conflict 
ProteomicsCTDP1 and RPB7 Stabilize Pol II and Permit Reinitiation
The mechanisms governing the termination and subsequent reinitiation of RNA polymerase II (Pol II) remain poorly understood. Here we found that depletion of RPB7 leads to the destabilization of Pol II’s largest subunit, RPB1. This destabilization is influenced by the loop regions of RPB7, CDK9, the ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD048909 | Pride
Label-free ms Ctdp1 Rpb7 Rpb1-turboid 
GenomicsGlobal mapping of H3K27ac and RPB1 occupancy upon WNK463 treatment
Global mapping of H3K27ac and RPB1 occupancy upon WNK463 treatment
PRJNA1023927 | ENA
TranscriptomicsDeconvolution of ChIP-chip MBF occupancies reveals the temporal recruitment of Rep2 at the MBF-target genes
Deconvolution analysis using Rpb1 ChIP-chip results distinguishes the Cdc10 bindings at the Rpb1-poor loci (promoters) from those at the Rpb1-rich loci (intragenic sequences). Importantly, Res1 binding at the Rpb1-poor loci, but not at the Rpb1-rich loci, are dependent on the Cdc10 function, suggest...
ORGANISM(S): Schizosaccharomyces pombe 
2010-11-26 | E-GEOD-9912 | biostudies-arrayexpress
TranscriptomicsChIP-chip data of Rrm3-Flag in wild-type and rpb1-1 cells
Transcription is a major contributor to genome instability.A main cause of transcription-associated instability relies on the capacity of transcription to stall replication. Such genome instability is increased in RNAPII mutants. ChIP-chips performed in asynchronous cultures showed an increase of th...
ORGANISM(S): Saccharomyces cerevisiae 
2014-12-04 | E-GEOD-55184 | biostudies-arrayexpress
GenomicsThe consequences of RPB1-CTD truncation for human transcriptome dynamics
The consequences of RPB1-CTD truncation for human transcriptome dynamics
PRJNA667687 | ENA
UnknownMutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil.
Not available
S-EPMC1456368 | biostudies-literature
TranscriptomicsThe RPB2 flap loop of human RNA polymerase II is dispensable for transcription initiation and elongation.
Deletion of the flap loop in the Rp2 subunit of human RNAPII did not alter the ability of human RNAPII to initiate transcription or elongate the initiated transcripts in vivo and in vitro, and was also dispensable for elongation factor-mediated enhancement and inhibition of transcript elongation in ...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-29734 | biostudies-arrayexpress
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