Sort   by:  
 Page size 
ProteomicsCTDP1 and RPB7 Stabilize Pol II and Permit Reinitiation
The mechanisms governing the termination and subsequent reinitiation of RNA polymerase II (Pol II) remain poorly understood. Here we found that depletion of RPB7 leads to the destabilization of Pol II’s largest subunit, RPB1. This destabilization is influenced by the loop regions of RPB7, CDK9, the ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD048909 | Pride
Label-free ms Ctdp1 Rpb7 Rpb1-turboid 
ProteomicsThe Plasmodium falciparum Nuclear Protein Phosphatase NIF4 is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity
Artemisinin resistance in Plasmodium falciparum, clinically presented as prolonged parasite clearance half-life, has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNI...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-07-23 | PXD033957 | Pride
Malaria  protein phosphatase  invasion  rna polymerase ii  asexual development 
ProteomicsThe Plasmodium falciparum Nuclear Protein Phosphatase NIF4 is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity
Artemisinin resistance in Plasmodium falciparum, clinically presented as prolonged parasite clearance half-life, has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNI...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-07-23 | PXD030249 | Pride
Malaria  protein phosphatase  invasion  rna polymerase ii  asexual development 
ProteomicsThe Plasmodium falciparum Nuclear Protein Phosphatase NIF4 is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity
Artemisinin resistance in Plasmodium falciparum, clinically presented as prolonged parasite clearance half-life, has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNI...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-07-23 | PXD034167 | Pride
Malaria  protein phosphatase  invasion  rna polymerase ii  asexual development 
Sort   by:  
 Page size