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ProteomicsCTDP1 and RPB7 Stabilize Pol II and Permit Reinitiation
The mechanisms governing the termination and subsequent reinitiation of RNA polymerase II (Pol II) remain poorly understood. Here we found that depletion of RPB7 leads to the destabilization of Pol II’s largest subunit, RPB1. This destabilization is influenced by the loop regions of RPB7, CDK9, the ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD048909 | Pride
Label-free ms Ctdp1 Rpb7 Rpb1-turboid 
TranscriptomicsGenome-associated RNA Polymerase II includes the dissociable Rpb4/7 subcomplex
Yeast RNA polymerase (Pol) II consists of a ten-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immuno-precipitation coupled to h...
ORGANISM(S): Saccharomyces cerevisiae 
2008-07-29 | E-GEOD-12060 | biostudies-arrayexpress
Transcriptomics4tU RNA-seq from wild-type and Rpb7-QHF cells
Our structural and biochemical studies show that S. cerevisiae RNA Polymerase II (RNAPII) homodimerizes through the stalk domain (formed by the Rpb4-Rpb7 subunits). To explore the biological impact of disrupting this interaction we introduced a triple point mutation at the RNAPII dimerization interf...
ORGANISM(S): Saccharomyces cerevisiae S288C 
2023-12-31 | E-MTAB-13370 | biostudies-arrayexpress
GenomicsChIP-seq of RNA Polymerase II (Rpb3) from wild-type and Rpb7-QHF cells
Our structural and biochemical studies show that S. cerevisiae RNA Polymerase II (RNAPII) homodimerizes through the stalk domain (formed by the Rpb4-Rpb7 subunits). To explore the biological impact of disrupting this interaction we introduced a triple point mutation at the RNAPII dimerization interf...
ORGANISM(S): Saccharomyces cerevisiae S288C 
2023-12-31 | E-MTAB-13369 | biostudies-arrayexpress
Genomics4tU RNA-seq from wild-type and Rpb7-QHF cells
4tU RNA-seq from wild-type and Rpb7-QHF cells
PRJEB66303 | ENA
GenomicsRPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChIP-Seq]
RPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChIP-Seq]
PRJNA926493 | ENA
GenomicsRPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [RNA-Seq]
RPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [RNA-Seq]
PRJNA926492 | ENA
GenomicsRPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChAR-Seq]
RPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChAR-Seq]
PRJNA926494 | ENA
UnknownCTDP1 and RPB7 stabilize Pol II and permit reinitiation.
Not available
S-EPMC11880454 | biostudies-literature
UnknownRpb7 represses transcription-coupled nucleotide excision repair.
Not available
S-EPMC10382679 | biostudies-literature
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