Sort   by:  
 Page size 
ProteomicsThe mass spectrometry analysis of CTDP1 function
We previously identified an interaction between the RNA polymerase II (Pol II) subunit RPB7 and the phosphatase CTDP1 in regulating transcription termination-reinitiation. Here, we establish that CTDP1 dephosphorylates a unique Pol II phospho-isoform modified at Tyr1, Ser5, and Ser7 of its C-termina...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-07-10 | PXD071392 | Pride
Pol ii Mediator Ctdp1 
ProteomicsCTDP1 BRCT domain PPI - CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI
The BRCT domain is commonly found in DNA damage response proteins, but its role in the phosphatase CTDP1 is unknown. This project examined the protein-protein interactions (PPI) associated with the CTDP1 BRCT domain region only and identified 106 significant interacting partners. Many of these partn...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD009541 | Pride
Brct dna damage lc-msms 
ProteomicsCTDP1 and RPB7 Stabilize Pol II and Permit Reinitiation
The mechanisms governing the termination and subsequent reinitiation of RNA polymerase II (Pol II) remain poorly understood. Here we found that depletion of RPB7 leads to the destabilization of Pol II’s largest subunit, RPB1. This destabilization is influenced by the loop regions of RPB7, CDK9, the ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD048909 | Pride
Label-free ms Ctdp1 Rpb7 Rpb1-turboid 
UnknownCTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.
Not available
S-EPMC6584691 | biostudies-literature
UnknownCtdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.
Not available
S-EPMC7803460 | biostudies-literature
UnknownCTDP1 and RPB7 stabilize Pol II and permit reinitiation.
Not available
S-EPMC11880454 | biostudies-literature
GenomicsCTDP1 governs a unique RNAPII phospho-form and coordinates Mediator recruitment, transcription efficiency, and splicing
We previously reported that the RNA polymerase II (Pol II) subunit RPB7 interacts with the phosphatase CTDP1 to regulate transcription termination-reinitiation. Here, we demonstrate that CTDP1 specifically dephosphorylates a unique phospho-isoform of Pol II, which is modified at tyrosine 1, serine 5...
ORGANISM(S): Mus musculus 
2025-12-08 | GSE312502 | GEO
GenomicsRPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChIP-Seq]
RPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChIP-Seq]
PRJNA926493 | ENA
GenomicsRPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [RNA-Seq]
RPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [RNA-Seq]
PRJNA926492 | ENA
GenomicsRPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChAR-Seq]
RPB7/CTDP1 stabilizes and licenses Pol II termination to reinitiation [ChAR-Seq]
PRJNA926494 | ENA
Sort   by:  
 Page size