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This SuperSeries is composed of the following subset Series: GSE21122: Whole-transcript expression data for soft-tissue sarcoma tumors and control normal fat specimens GSE21123: Affymetrix SNP array data for soft tissue sarcoma samples Refer to individual Series
ORGANISM(S): Homo sapiens 
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
UQCRH, also called the hinge protein, is a small subunit of Ubiquinol—cytochrome-c reductase (complex III). Here we used a complexome analysis of primary and immortalized fibroblasts from patients with a homozygous 2 exon deletion in the UQCRH gene and analyzed complex III assembly and altered supe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-20 | PXD022856 | Pride
Soft tissue sarcomas are aggressive mesenchymal cancers that affect more than 10,600 new patients per year in the US, about 40% of whom will die of their disease. Soft tissue sarcomas exhibit remarkable histologic diversity, with more than 50 recognized subtypes, but our knowledge of their genomic a...
ORGANISM(S): Homo sapiens 
The ATR-CHK1 signalling pathway responds to single strand DNA breaks and is required for cancer cells to survive the high levels of DNA replication stress and genomic instability resulting from the activity of oncogenes such as MYC. For this reason, inhibitors of CHK1 have great potential as anti-c...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-19 | PXD026203 | Pride
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