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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
UnknownStructure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain.
Not available
S-EPMC3203816 | biostudies-literature
UnknownMRI Safety Considerations for Permanent Magnet Implants in Muscle.
Not available
S-EPMC12810996 | biostudies-literature
UnknownDeleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment.
Not available
S-EPMC5534361 | biostudies-literature
UnknownFungal organic acid uptake of mineral-derived K is dependent on distance from carbon hotspot.
Not available
S-EPMC10653886 | biostudies-literature
UnknownMonocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition.
Not available
S-EPMC8410063 | biostudies-literature
UnknownPDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity.
Not available
S-EPMC6964506 | biostudies-literature
ProteomicsHuman Neutrophils in Pulmonary Arterial Hypertension by LC-MSMS
Neutrophil elastase (NE) is implicated in pulmonary arterial hypertension (PAH) but the role of neutrophils in the pathogenesis of PAH is unclear. Here we show that neutrophils from PAH vs. control subjects produce and release increased NE associated with enhanced extracellular trap formation. PAH n...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD023134 | Pride
Lc-msms Pulmonary arterial hypertension Neutrophils 
MetabolomicsDynamic utilization of low-molecular-weight organic substrates across a microbial growth rate gradient

AIM: Low-molecular-weight organic substances (LMWOSs) are at the nexus between micro-organisms, plant roots, detritus and the soil mineral matrix. The nominal oxidation state of carbon (NOSC) has been suggested as a potential parameter for modelling microbial uptake rates of LMWO...

2023-08-14 | MTBLS3558 | MetaboLights
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