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UnknownMulticenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Pravastatin Added to First-Line Standard Chemotherapy in Small-Cell Lung Cancer (LUNGSTAR).
Not available
S-EPMC5455702 | biostudies-literature
TranscriptomicsL-Glutamine metabolism and its regulation in C. glutamicum
Corynebacterium glutamicum, a gram-positive soil bacterium used for the industrial production of amino acids such as L-glutamate and L-lysine, is able to use a number of different nitrogen sources, such as ammonium, urea, or creatinine. In this communication, we show that L-glutamine serves as an ex...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2010-10-05 | E-GEOD-19779 | biostudies-arrayexpress
ProteomicsMetabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
PFA ependymomas are a lethal glial malignancy of the hindbrain found in babies and toddlers. Lacking any highly recurrent somatic mutations, PFAs have been proposed as a largely epigenetically driven tumor type. An almost complete lack of model systems has inhibited discovery of novel PFA therapies....
ORGANISM(S): Homo sapiens (Human) 
2020-08-13 | PXD018191 | Pride
Proteomics H3k27 methylation and acetylation Pfa ependymomas 
UnknownThe Effect of Lipid Modification on Peripheral Artery Disease after Endovascular Intervention Trial (ELIMIT).
Not available
S-EPMC4545656 | biostudies-literature
Genomicsena-DATASET-dkfz_b062-23-02-2018-16:41:10:412-192 - samples
This dataset contains ChIP sequencing data from 24 patients. ChIP of 5–10 mg flash-frozen primary ependymoma tumour was performed using 5 mg H3K27ac antibody per ChIP experiment. The enriched DNA has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to two lanes per sampl...
EGAD00001003979 | EGA
ProteomicsTIMELESS haploinsufficiency induces a PARG-dependency that is rescued by nucleoside supplementation, thus mimicking intrinsic PARG inhibitor sensitivity of ovarian cancer cells
A subset of cancer cells are intrinsically sensitive to inhibitors targeting PARG, the poly(ADP-ribose) glycohydrolase that degrades PAR chains. Sensitivity is accompanied by persistent DNA replication stress, and can be induced by inhibition of TIMELESS, a replisome accelerator. However, the nature...
ORGANISM(S): Homo sapiens (Human) 
2024-06-28 | PXD049682 | Pride
Parg inhibitor Dna replication Adp-ribosylation dda Ethcd Hgsoc Replication stress Lc-ms/ms 
UnknownLongitudinal Measurements of Glucocerebrosidase activity in Parkinson's patients.
Not available
S-EPMC7545591 | biostudies-literature
GenomicsEpigenomic Alterations Define Lethal CIMP positive Ependymomas of Infancy
Ependymomas are common childhood brain tumors that occur throughout the nervous system, but are most common in the pediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome se...
ORGANISM(S): Homo sapiens 
2014-03-15 | E-GEOD-55920 | biostudies-arrayexpress
TranscriptomicsA Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory
LSD1n regulates transcriptional elongation by removing H4K20 methylation. Identification of genome-wide binding sites of LSD1, and examination of the histone modifications upon LSD1n deletion in primary cortical neurons
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-63271 | biostudies-arrayexpress
ProteomicsMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled by analysis of gene copy number variation, whole exome sequence, methylome, transcriptome, proteome, and phospho(Tyr)-proteome. Proteome profiling resolved the known major histology subtypes and r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-11-24 | PXD016579 | Pride
Nsclc Tmt Lung Pdx 
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